METTL5 Regulates Cranial Suture Fusion Via Wnt Signaling

Overview

Journal Fundam Res

Date 2024 Jun 27

PMID 38933773

Authors

Kexin Lei

Ruoshi Xu

Qian Wang

Qiuchan Xiong

Xinyi Zhou

Qiwen Li

Dutmanee Seriwatanachai

Shuibin Lin

Chenchen Zhou

Quan Yuan

Affiliations

Soon will be listed here.

Abstract

METTL5 is a methyltransferase that mediates eukaryotic 18S ribosomal RNA mA modification, and its mutations lead to intellectual disability, microcephaly, and facial dysmorphism in patients. However, the role of METTL5 in craniofacial development remains poorly understood. This study demonstrates that knockout mice exhibit poor ossification, widened cranial sutures, and a cleidocranial dysplasia-like phenotype. Deletion of leads to increased proliferation and decreased osteogenic differentiation of suture mesenchymal stem cells. Mechanistically, we find that Wnt signaling is significantly downregulated after knockout. Overall, we reveal an essential role of METTL5 in craniofacial development and osteogenic differentiation of suture mesenchymal stem cells, making METTL5 a potential diagnostic and therapeutic target for craniofacial developmental diseases.

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