Modulatory Roles of , , , and Gene Expression in Metabolic-Associated Fatty Liver Disease and COVID-19 Outcomes

Overview

Journal Viruses

Publisher MDPI

Specialty Microbiology

Date 2024 Jun 27

PMID 38932276

Authors

Mykhailo Buchynskyi

Valentyn Oksenych

Iryna Kamyshna

Ihor Vorobets

Iryna Halabitska

Oleksandr Kamyshnyi

Affiliations

Soon will be listed here.

Abstract

Methods: We investigated gene expression levels of , , , and in patients with MAFLD and COVID-19 compared to controls. We examined associations between gene expression and clinical outcomes.

Results: COVID-19 patients displayed altered expression, potentially impacting immune response and recovery. Downregulated in patients with MAFLD correlated with increased coagulation parameters. Elevated expression in patients with MAFLD was linked to specific immune cell populations and hospital stay duration. A significantly lower expression was observed in both MAFLD and severe COVID-19.

Conclusion: Our findings suggest potential modulatory roles for , , and in COVID-19 and MAFLD.

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