Antitumoral-Embedded Biopolymeric Spheres for Implantable Devices

Overview

Journal Pharmaceutics

Publisher MDPI

Date 2024 Jun 27

PMID 38931875

Authors

Valentina Grumezescu

Oana Gherasim

Bianca Galateanu

Ariana Hudita

Affiliations

Soon will be listed here.

Abstract

The bioactive surface modification of implantable devices paves the way towards the personalized healthcare practice by providing a versatile and tunable approach that increase the patient outcome, facilitate the medical procedure, and reduce the indirect or secondary effects. The purpose of our study was to assess the performance of composite coatings based on biopolymeric spheres of poly(lactide-co-glycolide) embedded with hydroxyapatite (HA) and methotrexate (MTX). Bio-simulated tests performed for up to one week evidenced the gradual release of the antitumor drug and the biomineralization potential of PLGA/HA-MTX sphere coatings. The composite materials proved superior biocompatibility and promoted enhanced cell adhesion and proliferation with respect to human preosteoblast and osteosarcoma cell lines when compared to pristine titanium.

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