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Orthologs at the Base of the Olfactores Clade

Overview
Journal Genes (Basel)
Publisher MDPI
Date 2024 Jun 27
PMID 38927593
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Abstract

Tunicate orthologs in the human genome comprise just 84 genes of the 19,872 protein-coding genes and 23 of the 16,528 non-coding genes, yet they stand at the base of the Olfactores clade, which radiated to generate thousands of tunicate and vertebrate species. What were the powerful drivers among these genes that enabled this process? Many of these orthologs are present in gene families. We discuss the biological role of each family and the orthologs' quantitative contribution to the family. Most important was the evolution of a second type of cadherin. This, a Type II cadherin, had the property of detaching the cell containing that cadherin from cells that expressed the Type I class. The set of such Type II cadherins could now detach and move away from their Type I neighbours, a process which would eventually evolve into the formation of the neural crest, "the fourth germ layer", providing a wide range of possibilities for further evolutionary invention. A second important contribution were key additions to the broad development of the muscle and nerve protein and visual perception toolkits. These developments in mobility and vision provided the basis for the development of the efficient predatory capabilities of the Vertebrata.

References
1.
Matsuoka H, Yamaoka A, Hamashima T, Shima A, Kosako M, Tahara Y . EGF-Dependent Activation of ELK1 Contributes to the Induction of CLDND1 Expression Involved in Tight Junction Formation. Biomedicines. 2022; 10(8). PMC: 9329870. DOI: 10.3390/biomedicines10081792. View

2.
Slingsby C, Wistow G, Clark A . Evolution of crystallins for a role in the vertebrate eye lens. Protein Sci. 2013; 22(4):367-80. PMC: 3610043. DOI: 10.1002/pro.2229. View

3.
Satou Y, Imai K . Ascidian Zic Genes. Adv Exp Med Biol. 2018; 1046:87-106. DOI: 10.1007/978-981-10-7311-3_6. View

4.
Horie T, Sakurai D, Ohtsuki H, Terakita A, Shichida Y, Usukura J . Pigmented and nonpigmented ocelli in the brain vesicle of the ascidian larva. J Comp Neurol. 2008; 509(1):88-102. DOI: 10.1002/cne.21733. View

5.
Scales S, Hesser B, Masuda E, Scheller R . Amisyn, a novel syntaxin-binding protein that may regulate SNARE complex assembly. J Biol Chem. 2002; 277(31):28271-9. DOI: 10.1074/jbc.M204929200. View