Synthesis of Ultrasmall Cerium Oxide Nanoparticles in Deep Eutectic Solvent and Their Application in an Electrochemical Sensor to Detect Dopamine in Biological Fluid

Overview

Journal Mikrochim Acta

Specialties Biotechnology
Chemistry

Date 2024 Jun 26

PMID 38926184

Authors

Paulo Cardoso Gomes-Junior

Gustavo Patelli Longatto

Karen Kenlderi de Lima Augusto

Josias da Silveira Rocha

Evandro Piccin

Orlando Fatibello-Filho

Affiliations

Soon will be listed here.

Abstract

A solvothermal synthesis of ultrasmall cerium oxide nanoparticles (USCeOxNPs) with an average size of 0.73 ± 0.07 nm using deep eutectic solvent (DES) as a stabilizing medium at a temperature of 90 ºC is reported. Transmission electron microscopy (TEM) and energy dispersive spectroscopy (EDS) were used to morphologically characterize the USCeOxNPs. These revealed approximately spherical shapes with emission lines characteristic of cerium. Selected area electron diffraction (SAED) was used to determine the crystalline structure of the cerium oxide nanoparticles (CeONPs), revealing the presence of crystalline cubic structures. The USCeOxNPs-DES/CB film was characterized by scanning electron microscopy (SEM), which demonstrated the spherical characteristic of CB with layers slightly covered by DES residues. DES was characterized by Fourier transform infrared (FT-IR) and nuclear magnetic resonance (NMR), indicating its formation through hydrogen bonds between the precursors. An electrochemical sensor for dopamine (DA) determination in biological fluids was developed using the USCeOxNPs together with carbon black (CB). An enhanced current response was observed on DA voltammetric determination, and this can be attributed to the USCeOxNPs. This sensor displayed linear responses for DA in the range 5.0 × 10 mol L to 3.2 × 10 mol L, with a limit of detection of 80 nmol L. Besides detectability, excellent performances were verified for repeatability and anti-interference. The sensor based on USCeOxNPs synthesized in DES in a simpler and environmentally friendly way was successfully applied to determine DA in biological matrix.

References

Duan H, Wang D, Li Y . Green chemistry for nanoparticle synthesis. Chem Soc Rev. 2015; 44(16):5778-92. DOI: 10.1039/c4cs00363b. View

Gao Y, Chen K, Ma J, Gao F . Cerium oxide nanoparticles in cancer. Onco Targets Ther. 2014; 7:835-40. PMC: 4043807. DOI: 10.2147/OTT.S62057. View

Celardo I, Traversa E, Ghibelli L . Cerium oxide nanoparticles: a promise for applications in therapy. J Exp Ther Oncol. 2011; 9(1):47-51. View

Hirst S, Karakoti A, Tyler R, Sriranganathan N, Seal S, Reilly C . Anti-inflammatory properties of cerium oxide nanoparticles. Small. 2009; 5(24):2848-56. DOI: 10.1002/smll.200901048. View

Lavanya N, Nizeyimana Claude J, Sekar C . Electrochemical determination of purine and pyrimidine bases using copper doped cerium oxide nanoparticles. J Colloid Interface Sci. 2018; 530:202-211. DOI: 10.1016/j.jcis.2018.06.046. View

Ziyatdinova G, Gimadutdinova L . Cerium(IV) and Iron(III) Oxides Nanoparticles Based Voltammetric Sensor for the Sensitive and Selective Determination of Lipoic Acid. Sensors (Basel). 2021; 21(22). PMC: 8621773. DOI: 10.3390/s21227639. View

Beatto T, Gomes W, Etchegaray A, Gupta R, Mendes R . Dopamine levels determined in synthetic urine using an electrochemical tyrosinase biosensor based on ZnO@Au core-shell. RSC Adv. 2023; 13(47):33424-33429. PMC: 10644153. DOI: 10.1039/d3ra06277e. View

Abranches D, Silva L, Martins M, Coutinho J . Differences on the impact of water on the deep eutectic solvents betaine/urea and choline/urea. J Chem Phys. 2021; 155(3):034501. DOI: 10.1063/5.0052303. View

Goharshadi E, Samiee S, Nancarrow P . Fabrication of cerium oxide nanoparticles: characterization and optical properties. J Colloid Interface Sci. 2011; 356(2):473-80. DOI: 10.1016/j.jcis.2011.01.063. View

10.

Gao F, Lu Q, Komarneni S . Fast synthesis of cerium oxide nanoparticles and nanorods. J Nanosci Nanotechnol. 2007; 6(12):3812-9. DOI: 10.1166/jnn.2006.609. View

11.

Parimi D, Sundararajan V, Sadak O, Gunasekaran S, Sheik Mohideen S, Sundaramurthy A . Synthesis of Positively and Negatively Charged CeO Nanoparticles: Investigation of the Role of Surface Charge on Growth and Development of . ACS Omega. 2019; 4(1):104-113. PMC: 6649140. DOI: 10.1021/acsomega.8b02747. View

12.

Ferreira L, Silva P, Augusto K, Gomes-Junior P, Farra S, Silva T . Using nanostructured carbon black-based electrochemical (bio)sensors for pharmaceutical and biomedical analyses: A comprehensive review. J Pharm Biomed Anal. 2022; 221:115032. DOI: 10.1016/j.jpba.2022.115032. View

13.

Figueiredo-Filho L, Silva T, Vicentini F, Fatibello-Filho O . Simultaneous voltammetric determination of dopamine and epinephrine in human body fluid samples using a glassy carbon electrode modified with nickel oxide nanoparticles and carbon nanotubes within a dihexadecylphosphate film. Analyst. 2014; 139(11):2842-9. DOI: 10.1039/c4an00229f. View

14.

Haghshenas E, Madrakian T, Afkhami A . Electrochemically oxidized multiwalled carbon nanotube/glassy carbon electrode as a probe for simultaneous determination of dopamine and doxorubicin in biological samples. Anal Bioanal Chem. 2016; 408(10):2577-86. DOI: 10.1007/s00216-016-9361-y. View

15.

Medeiros R, Matos R, Benchikh A, Saidani B, Debiemme-Chouvy C, Deslouis C . Amorphous carbon nitride as an alternative electrode material in electroanalysis: simultaneous determination of dopamine and ascorbic acid. Anal Chim Acta. 2013; 797:30-9. DOI: 10.1016/j.aca.2013.08.018. View