Molecular and Evolutionary Analysis of RNA-Protein Interactions in Telomerase Regulation

Overview

Journal Noncoding RNA

Date 2024 Jun 26

PMID 38921833

Authors

Justin A Davis

Kausik Chakrabarti

Affiliations

Soon will be listed here.

Abstract

Telomerase is an enzyme involved in the maintenance of telomeres. Telomere shortening due to the end-replication problem is a threat to the genome integrity of all eukaryotes. Telomerase inside cells depends on a myriad of protein-protein and RNA-protein interactions to properly assemble and regulate the function of the telomerase holoenzyme. These interactions are well studied in model eukaryotes, like humans, yeast, and the ciliated protozoan known as . Emerging evidence also suggests that deep-branching eukaryotes, such as the parasitic protist require conserved and novel RNA-binding proteins for the assembly and function of their telomerase. In this review, we will discuss telomerase regulatory pathways in the context of telomerase-interacting proteins, with special attention paid to RNA-binding proteins. We will discuss these interactors on an evolutionary scale, from parasitic protists to humans, to provide a broader perspective on the extensive role that protein-protein and RNA-protein interactions play in regulating telomerase activity in eukaryotes.

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