Inbred Mouse Models in Research

Overview

Journal J Fungi (Basel)

Date 2024 Jun 26

PMID 38921412

Authors

Minna Ding

Kirsten Nielsen

Affiliations

Soon will be listed here.

Abstract

Animal models are frequently used as surrogates to understand human disease. In the fungal pathogen species complex, several variations of a mouse model of disease were developed that recapitulate different aspects of human disease. These mouse models have been implemented using various inbred and outbred mouse backgrounds, many of which have genetic differences that can influence host response and disease outcome. In this review, we will discuss the most commonly used inbred mouse backgrounds in infection models.

References

Glass A, Coombs W, Taffet S . Spontaneous cardiac calcinosis in BALB/cByJ mice. Comp Med. 2013; 63(1):29-37. PMC: 3567374. View

Jain A, Zhang Y, Fields W, McNamara D, Choe M, Chen G . Th2 but not Th1 immune bias results in altered lung functions in a murine model of pulmonary Cryptococcus neoformans infection. Infect Immun. 2009; 77(12):5389-99. PMC: 2786439. DOI: 10.1128/IAI.00809-09. View

Piehler D, Grahnert A, Eschke M, Richter T, Kohler G, Stenzel W . T1/ST2 promotes T helper 2 cell activation and polyfunctionality in bronchopulmonary mycosis. Mucosal Immunol. 2012; 6(2):405-14. DOI: 10.1038/mi.2012.84. View

Xu J, Hissong R, Bareis R, Creech A, Goughenour K, Freeman C . Batf3-dependent orchestration of the robust Th1 responses and fungal control during cryptococcal infection, the role of cDC1. mBio. 2024; 15(3):e0285323. PMC: 10936214. DOI: 10.1128/mbio.02853-23. View

Wiesner D, Specht C, Lee C, Smith K, Mukaremera L, Lee S . Chitin recognition via chitotriosidase promotes pathologic type-2 helper T cell responses to cryptococcal infection. PLoS Pathog. 2015; 11(3):e1004701. PMC: 4357429. DOI: 10.1371/journal.ppat.1004701. View

Movahed E, Cheok Y, Tan G, Lee C, Cheong H, Velayuthan R . Lung-infiltrating T helper 17 cells as the major source of interleukin-17A production during pulmonary Cryptococcus neoformans infection. BMC Immunol. 2018; 19(1):32. PMC: 6225695. DOI: 10.1186/s12865-018-0269-5. View

Coggins C . A further review of inhalation studies with cigarette smoke and lung cancer in experimental animals, including transgenic mice. Inhal Toxicol. 2010; 22(12):974-83. DOI: 10.3109/08958378.2010.501831. View

Pandey A, Ding S, Qin Q, Gupta R, Gomez G, Lin F . Global Reprogramming of Host Kinase Signaling in Response to Fungal Infection. Cell Host Microbe. 2017; 21(5):637-649.e6. PMC: 5538893. DOI: 10.1016/j.chom.2017.04.008. View

Specht C, Lee C, Huang H, Hester M, Liu J, Luckie B . Vaccination with Recombinant Proteins in Glucan Particles Protects Mice against Cryptococcosis in a Manner Dependent upon Mouse Strain and Cryptococcal Species. mBio. 2017; 8(6). PMC: 5705919. DOI: 10.1128/mBio.01872-17. View

10.

Braley-Mullen H, Johnson M, Sharp G, Kyriakos M . Induction of experimental autoimmune thyroiditis in mice with in vitro activated splenic T cells. Cell Immunol. 1985; 93(1):132-43. DOI: 10.1016/0008-8749(85)90394-6. View

11.

Colby J, Gott K, Wilder J, Levy B . Lipoxin Signaling in Murine Lung Host Responses to Cryptococcus neoformans Infection. Am J Respir Cell Mol Biol. 2015; 54(1):25-33. PMC: 4742922. DOI: 10.1165/rcmb.2014-0102OC. View

12.

Neal L, Qiu Y, Chung J, Xing E, Cho W, Malachowski A . T Cell-Restricted Notch Signaling Contributes to Pulmonary Th1 and Th2 Immunity during Infection. J Immunol. 2017; 199(2):643-655. PMC: 5513675. DOI: 10.4049/jimmunol.1601715. View

13.

Heung L, Hohl T . Inflammatory monocytes are detrimental to the host immune response during acute infection with Cryptococcus neoformans. PLoS Pathog. 2019; 15(3):e1007627. PMC: 6428256. DOI: 10.1371/journal.ppat.1007627. View

14.

Leopold Wager C, Hole C, Wozniak K, Olszewski M, Wormley Jr F . STAT1 signaling is essential for protection against Cryptococcus neoformans infection in mice. J Immunol. 2014; 193(8):4060-71. PMC: 4185263. DOI: 10.4049/jimmunol.1400318. View

15.

Stukes S, Coelho C, Rivera J, Jedlicka A, Hajjar K, Casadevall A . The Membrane Phospholipid Binding Protein Annexin A2 Promotes Phagocytosis and Nonlytic Exocytosis of Cryptococcus neoformans and Impacts Survival in Fungal Infection. J Immunol. 2016; 197(4):1252-61. PMC: 5160961. DOI: 10.4049/jimmunol.1501855. View

16.

Hoger H . Genetic drift in an outbred stock of mice. Jikken Dobutsu. 1992; 41(2):215-20. View

17.

Li Y, Wang Z, Li F, Zhou L, Jiang Y, Yu Y . Inhibition of myeloid-derived suppressor cell arginase-1 production enhances T-cell-based immunotherapy against Cryptococcus neoformans infection. Nat Commun. 2022; 13(1):4074. PMC: 9283461. DOI: 10.1038/s41467-022-31723-4. View

18.

Hansakon A, Png C, Zhang Y, Angkasekwinai P . Macrophage-Derived Osteopontin Influences the Amplification of -Promoting Type 2 Immune Response. J Immunol. 2021; 207(8):2107-2117. DOI: 10.4049/jimmunol.2100202. View

19.

Eschke M, Piehler D, Schulze B, Richter T, Grahnert A, Protschka M . A novel experimental model of Cryptococcus neoformans-related immune reconstitution inflammatory syndrome (IRIS) provides insights into pathogenesis. Eur J Immunol. 2015; 45(12):3339-50. DOI: 10.1002/eji.201545689. View

20.

Kitai Y, Sato K, Tanno D, Yuan X, Umeki A, Kasamatsu J . Role of Dectin-2 in the Phagocytosis of Cryptococcus neoformans by Dendritic Cells. Infect Immun. 2021; 89(10):e0033021. PMC: 8445189. DOI: 10.1128/IAI.00330-21. View