Impact of Combined Modulation of Two Potassium Ion Currents on Spiral Waves and Turbulent States in the Heart

Overview

Journal Entropy (Basel)

Publisher MDPI

Date 2024 Jun 26

PMID 38920457

Authors

Jing Bai

Chunfu Zhang

Yanchun Liang

Adriano Tavares

Lidong Wang

Affiliations

Soon will be listed here.

Abstract

In the realm of cardiac research, the control of spiral waves and turbulent states has been a persistent focus for scholars. Among various avenues of investigation, the modulation of ion currents represents a crucial direction. It has been proved that the methods involving combined control of currents are superior to singular approaches. While previous studies have proposed some combination strategies, further reinforcement and supplementation are required, particularly in the context of controlling arrhythmias through the combined regulation of two potassium ion currents. This study employs the Luo-Rudy phase I cardiac model, modulating the maximum conductance of the time-dependent potassium current and the time-independent potassium current, to investigate the effects of this combined modulation on spiral waves and turbulent states. Numerical simulation results indicate that, compared to modulating a single current, combining reductions in the conductance of two potassium ion currents can rapidly control spiral waves and turbulent states in a short duration. This implies that employing blockers for both potassium ion currents concurrently represents a more efficient control strategy. The control outcomes of this study represent a novel and effective combination for antiarrhythmic interventions, offering potential avenues for new antiarrhythmic drug targets.

References

Li W, Janardhan A, Fedorov V, Sha Q, Schuessler R, Efimov I . Low-energy multistage atrial defibrillation therapy terminates atrial fibrillation with less energy than a single shock. Circ Arrhythm Electrophysiol. 2011; 4(6):917-25. PMC: 3253458. DOI: 10.1161/CIRCEP.111.965830. View

Madhvani R, Xie Y, Pantazis A, Garfinkel A, Qu Z, Weiss J . Shaping a new Ca²⁺ conductance to suppress early afterdepolarizations in cardiac myocytes. J Physiol. 2011; 589(Pt 24):6081-92. PMC: 3286687. DOI: 10.1113/jphysiol.2011.219600. View

Grandi E, Pasqualini F, Bers D . A novel computational model of the human ventricular action potential and Ca transient. J Mol Cell Cardiol. 2009; 48(1):112-21. PMC: 2813400. DOI: 10.1016/j.yjmcc.2009.09.019. View

Song Z, Qu Z . Delayed global feedback in the genesis and stability of spatiotemporal excitation patterns in paced biological excitable media. PLoS Comput Biol. 2020; 16(10):e1007931. PMC: 7561267. DOI: 10.1371/journal.pcbi.1007931. View

Braunschweig F, Boriani G, Bauer A, Hatala R, Herrmann-Lingen C, Kautzner J . Management of patients receiving implantable cardiac defibrillator shocks: recommendations for acute and long-term patient management. Europace. 2010; 12(12):1673-90. DOI: 10.1093/europace/euq316. View

Davidenko J, Kent P, Chialvo D, Michaels D, Jalife J . Sustained vortex-like waves in normal isolated ventricular muscle. Proc Natl Acad Sci U S A. 1990; 87(22):8785-9. PMC: 55044. DOI: 10.1073/pnas.87.22.8785. View

Pan D, Gao X, Feng X, Pan J, Zhang H . Removal of pinned scroll waves in cardiac tissues by electric fields in a generic model of three-dimensional excitable media. Sci Rep. 2016; 6:21876. PMC: 4764807. DOI: 10.1038/srep21876. View

Vandersickel N, Bossu A, De Neve J, Dunnink A, Meijborg V, van der Heyden M . Short-Lasting Episodes of Torsade de Pointes in the Chronic Atrioventricular Block Dog Model Have a Focal Mechanism, While Longer-Lasting Episodes Are Maintained by Re-Entry. JACC Clin Electrophysiol. 2018; 3(13):1565-1576. DOI: 10.1016/j.jacep.2017.06.016. View

Zhang H, Cao Z, Wu N, Ying H, Hu G . Suppress Winfree turbulence by local forcing excitable systems. Phys Rev Lett. 2005; 94(18):188301. DOI: 10.1103/PhysRevLett.94.188301. View

10.

Gray R . Termination of spiral wave breakup in a Fitzhugh-Nagumo model via short and long duration stimuli. Chaos. 2003; 12(3):941-951. DOI: 10.1063/1.1497836. View

11.

Luo C, Rudy Y . A model of the ventricular cardiac action potential. Depolarization, repolarization, and their interaction. Circ Res. 1991; 68(6):1501-26. DOI: 10.1161/01.res.68.6.1501. View

12.

Navarrete E, Liang P, Lan F, Sanchez-Freire V, Simmons C, Gong T . Screening drug-induced arrhythmia [corrected] using human induced pluripotent stem cell-derived cardiomyocytes and low-impedance microelectrode arrays. Circulation. 2013; 128(11 Suppl 1):S3-13. PMC: 3855862. DOI: 10.1161/CIRCULATIONAHA.112.000570. View

13.

Madhvani R, Angelini M, Xie Y, Pantazis A, Suriany S, Borgstrom N . Targeting the late component of the cardiac L-type Ca2+ current to suppress early afterdepolarizations. J Gen Physiol. 2015; 145(5):395-404. PMC: 4411259. DOI: 10.1085/jgp.201411288. View

14.

Yang K, Nerbonne J . Mechanisms contributing to myocardial potassium channel diversity, regulation and remodeling. Trends Cardiovasc Med. 2015; 26(3):209-18. PMC: 4715991. DOI: 10.1016/j.tcm.2015.07.002. View

15.

Yamazaki M, Honjo H, Ashihara T, Harada M, Sakuma I, Nakazawa K . Regional cooling facilitates termination of spiral-wave reentry through unpinning of rotors in rabbit hearts. Heart Rhythm. 2011; 9(1):107-14. PMC: 3328397. DOI: 10.1016/j.hrthm.2011.08.013. View

16.

Bohnen M, Stevenson W, Tedrow U, Michaud G, John R, Epstein L . Incidence and predictors of major complications from contemporary catheter ablation to treat cardiac arrhythmias. Heart Rhythm. 2011; 8(11):1661-6. DOI: 10.1016/j.hrthm.2011.05.017. View

17.

Boccia E, Luther S, Parlitz U . Modelling far field pacing for terminating spiral waves pinned to ischaemic heterogeneities in cardiac tissue. Philos Trans A Math Phys Eng Sci. 2017; 375(2096). PMC: 5434080. DOI: 10.1098/rsta.2016.0289. View

18.

Fenton F, Cherry E, Hastings H, Evans S . Multiple mechanisms of spiral wave breakup in a model of cardiac electrical activity. Chaos. 2003; 12(3):852-892. DOI: 10.1063/1.1504242. View

19.

Majumder R, Feola I, Teplenin A, de Vries A, Panfilov A, Pijnappels D . Optogenetics enables real-time spatiotemporal control over spiral wave dynamics in an excitable cardiac system. Elife. 2018; 7. PMC: 6195347. DOI: 10.7554/eLife.41076. View

20.

Horning M, Takagi S, Yoshikawa K . Controlling activation site density by low-energy far-field stimulation in cardiac tissue. Phys Rev E Stat Nonlin Soft Matter Phys. 2012; 85(6 Pt 1):061906. DOI: 10.1103/PhysRevE.85.061906. View