Research Progress on the Nonstructural Protein 1 (NS1) of Influenza a Virus

Overview

Journal Virulence

Specialty Microbiology

Date 2024 Jun 26

PMID 38918890

Authors

Xiaoyan Zhang

Yuying Zhang

Fanhua Wei

Affiliations

Soon will be listed here.

Abstract

Influenza A virus (IAV) is the leading cause of highly contagious respiratory infections, which poses a serious threat to public health. The non-structural protein 1 (NS1) is encoded by segment 8 of IAV genome and is expressed in high levels in host cells upon IAV infection. It is the determinant of virulence and has multiple functions by targeting type Ι interferon (IFN-I) and type III interferon (IFN-III) production, disrupting cell apoptosis and autophagy in IAV-infected cells, and regulating the host fitness of influenza viruses. This review will summarize the current research on the NS1 including the structure and related biological functions of the NS1 as well as the interaction between the NS1 and host cells. It is hoped that this will provide some scientific basis for the prevention and control of the influenza virus.

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