Garlic Bioactive Substances and Their Therapeutic Applications for Improving Human Health: a Comprehensive Review

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2024 Jun 25

PMID 38915405

Authors

Mohamed T El-Saadony

Ahmed M Saad

Sameh A Korma

Heba M Salem

Taia A Abd El-Mageed

Samar Sami Alkafaas

Mohamed I Elsalahaty

Sara Samy ElKafas

Walid F A Mosa

Ahmed Ezzat Ahmed

Betty T Mathew

Noor A Albastaki

Aysha A Alkuwaiti

Marawan K El-Tarabily

Synan F AbuQamar

Khaled A El-Tarabily

Salam A Ibrahim

Affiliations

Soon will be listed here.

Abstract

Garlic ( L.) is a widely abundant spice, known for its aroma and pungent flavor. It contains several bioactive compounds and offers a wide range of health benefits to humans, including those pertaining to nutrition, physiology, and medicine. Therefore, garlic is considered as one of the most effective disease-preventive diets. Many and studies have reported the sulfur-containing compounds, allicin and ajoene, for their effective anticancer, anti-diabetic, anti-inflammatory, antioxidant, antimicrobial, immune-boosting, and cardioprotective properties. As a rich natural source of bioactive compounds, including polysaccharides, saponins, tannins, linalool, geraniol, phellandrene, β-phellandrene, ajoene, alliin, S-allyl-mercapto cysteine, and β-phellandrene, garlic has many therapeutic applications and may play a role in drug development against various human diseases. In the current review, garlic and its major bioactive components along with their biological function and mechanisms of action for their role in disease prevention and therapy are discussed.

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References

Block E, Dethier B, Bechand B, Cotelesage J, George G, Goto K . Ajothiolanes: 3,4-Dimethylthiolane Natural Products from Garlic ( Allium sativum). J Agric Food Chem. 2018; 66(39):10193-10204. DOI: 10.1021/acs.jafc.8b03638. View

Pateiro M, Gomez B, Munekata P, Barba F, Putnik P, Bursac Kovacevic D . Nanoencapsulation of Promising Bioactive Compounds to Improve Their Absorption, Stability, Functionality and the Appearance of the Final Food Products. Molecules. 2021; 26(6). PMC: 7999092. DOI: 10.3390/molecules26061547. View

Miltonprabu S, Sumedha N, Senthilraja P . Diallyl trisulfide, a garlic polysulfide protects against As-induced renal oxidative nephrotoxicity, apoptosis and inflammation in rats by activating the Nrf2/ARE signaling pathway. Int Immunopharmacol. 2017; 50:107-120. DOI: 10.1016/j.intimp.2017.06.011. View

Abbasi A, Rad A, Ghasempour Z, Sabahi S, Kafil H, Hasannezhad P . The biological activities of postbiotics in gastrointestinal disorders. Crit Rev Food Sci Nutr. 2021; 62(22):5983-6004. DOI: 10.1080/10408398.2021.1895061. View

Nicastro H, Ross S, Milner J . Garlic and onions: their cancer prevention properties. Cancer Prev Res (Phila). 2015; 8(3):181-9. PMC: 4366009. DOI: 10.1158/1940-6207.CAPR-14-0172. View

Lawson L, Hunsaker S . Allicin Bioavailability and Bioequivalence from Garlic Supplements and Garlic Foods. Nutrients. 2018; 10(7). PMC: 6073756. DOI: 10.3390/nu10070812. View

Lu M, Pan J, Hu Y, Ding L, Li Y, Cui X . Advances in the study of vascular related protective effect of garlic (Allium sativum) extract and compounds. J Nutr Biochem. 2023; 124:109531. DOI: 10.1016/j.jnutbio.2023.109531. View

Karimi N, Jabbari V, Nazemi A, Ganbarov K, Karimi N, Tanomand A . Thymol, cardamom and Lactobacillus plantarum nanoparticles as a functional candy with high protection against Streptococcus mutans and tooth decay. Microb Pathog. 2020; 148:104481. DOI: 10.1016/j.micpath.2020.104481. View

Zhai H, Pan J, Pang E, Bai B . Lavage with allicin in combination with vancomycin inhibits biofilm formation by Staphylococcus epidermidis in a rabbit model of prosthetic joint infection. PLoS One. 2014; 9(7):e102760. PMC: 4099135. DOI: 10.1371/journal.pone.0102760. View

10.

Wang W, Cheng J, Zhu Y . The JNK Signaling Pathway Is a Novel Molecular Target for S-Propargyl- L-Cysteine, a Naturally-Occurring Garlic Derivatives: Link to Its Anticancer Activity in Pancreatic Cancer In Vitro and In Vivo. Curr Cancer Drug Targets. 2015; 15(7):613-23. DOI: 10.2174/1568009615666150602143943. View

11.

Fratianni F, Riccardi R, Spigno P, Ombra M, Cozzolino A, Tremonte P . Biochemical Characterization and Antimicrobial and Antifungal Activity of Two Endemic Varieties of Garlic (Allium sativum L.) of the Campania Region, Southern Italy. J Med Food. 2016; 19(7):686-91. DOI: 10.1089/jmf.2016.0027. View

12.

Staba E, Lash L, Staba J . A commentary on the effects of garlic extraction and formulation on product composition. J Nutr. 2001; 131(3s):1118S-9S. DOI: 10.1093/jn/131.3.1118S. View

13.

Yamaguchi Y, Hirata Y, Saito T, Kumagai H . Combined Effects of Amino Acids in Garlic and Buna-Shimeji ( on Suppression of CCl-Induced Hepatic Injury in Rats. Foods. 2021; 10(7). PMC: 8306630. DOI: 10.3390/foods10071491. View

14.

Park S, Seetharaman R, Ko M, Kim D, Kim T, Yoon M . Ethyl linoleate from garlic attenuates lipopolysaccharide-induced pro-inflammatory cytokine production by inducing heme oxygenase-1 in RAW264.7 cells. Int Immunopharmacol. 2014; 19(2):253-61. DOI: 10.1016/j.intimp.2014.01.017. View

15.

Lefer D . A new gaseous signaling molecule emerges: cardioprotective role of hydrogen sulfide. Proc Natl Acad Sci U S A. 2007; 104(46):17907-8. PMC: 2084269. DOI: 10.1073/pnas.0709010104. View

16.

Agarwal K . Therapeutic actions of garlic constituents. Med Res Rev. 1996; 16(1):111-24. DOI: 10.1002/(SICI)1098-1128(199601)16:1<111::AID-MED4>3.0.CO;2-5. View

17.

Cutler R, Wilson P . Antibacterial activity of a new, stable, aqueous extract of allicin against methicillin-resistant Staphylococcus aureus. Br J Biomed Sci. 2004; 61(2):71-4. DOI: 10.1080/09674845.2004.11732646. View

18.

Jakszyn P, Agudo A, Ibanez R, Garcia-Closas R, Pera G, Amiano P . Development of a food database of nitrosamines, heterocyclic amines, and polycyclic aromatic hydrocarbons. J Nutr. 2004; 134(8):2011-4. DOI: 10.1093/jn/134.8.2011. View

19.

Rabe S, Ghazanfari T, Siadat Z, Rastin M, Zamani Taghizadeh Rabe S, Mahmoudi M . Anti-inflammatory effect of garlic 14-kDa protein on LPS-stimulated-J774A.1 macrophages. Immunopharmacol Immunotoxicol. 2015; 37(2):158-64. DOI: 10.3109/08923973.2015.1005229. View

20.

Wu J, Liu Y, Dou Z, Wu T, Liu R, Sui W . Black garlic melanoidins prevent obesity, reduce serum LPS levels and modulate the gut microbiota composition in high-fat diet-induced obese C57BL/6J mice. Food Funct. 2020; 11(11):9585-9598. DOI: 10.1039/d0fo02379e. View