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Systematic Review of Long Term Sinonasal Outcomes in CRSwNP After Endoscopic Sinus Surgery: A Call for Unified and Standardized Criteria and Terms

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Abstract

Purpose Of Review: To present current evidence in long-term (> 5 years) results after endoscopic sinus surgery (ESS) focusing on Patients Reported Outcome Measures (PROMs) and other sinonasal outcomes while assessing the role of ESS in the treatment of CRSwNP, and identifying outcomes which affect the results of ESS and defining recommendations for future studies.

Recent Findings: Long-term results of ESS in CRSwNP can be branched in PROMs and other objective measurements. Despite the heterogeneity of reported outcomes make it difficult to perform comparisons and meta-analysis, ESS improves PROMs, including symptoms, QOL and olfaction. Objectives outcomes such as NPS, LMS, type of surgery, or recurrence and revision surgery don't have a clear role in long-term results. Clustering patients suggest asthma, N-ERD, allergy, eosinophil count and IL-5 could have a role in predicting recurrence and severe disease. Long-term studies of CRSwNP treated with ESS are scarce. There is a significant need to standardize the report of results. The use of tools as SNOT-22, NPS, validated smell tests, defined criteria for disease recurrence and control and ESS extension in a unified systematic way could allow better comparisons between treatments in the new era of biologics.

References
1.
Gevaert P, Omachi T, Corren J, Mullol J, Han J, Lee S . Efficacy and safety of omalizumab in nasal polyposis: 2 randomized phase 3 trials. J Allergy Clin Immunol. 2020; 146(3):595-605. DOI: 10.1016/j.jaci.2020.05.032. View

2.
Fokkens W, Viskens A, Backer V, Conti D, De Corso E, Gevaert P . EPOS/EUFOREA update on indication and evaluation of Biologics in Chronic Rhinosinusitis with Nasal Polyps 2023. Rhinology. 2023; 61(3):194-202. DOI: 10.4193/Rhin22.489. View

3.
Hopkins C, Slack R, Lund V, Brown P, Copley L, Browne J . Long-term outcomes from the English national comparative audit of surgery for nasal polyposis and chronic rhinosinusitis. Laryngoscope. 2009; 119(12):2459-65. DOI: 10.1002/lary.20653. View

4.
Tajudeen B, Ganti A, Kuhar H, Mahdavinia M, Heilingoetter A, Gattuso P . The presence of eosinophil aggregates correlates with increased postoperative prednisone requirement. Laryngoscope. 2018; 129(4):794-799. DOI: 10.1002/lary.27693. View

5.
Blomqvist E, Lundblad L, Anggard A, Haraldsson P, Stjarne P . A randomized controlled study evaluating medical treatment versus surgical treatment in addition to medical treatment of nasal polyposis. J Allergy Clin Immunol. 2001; 107(2):224-8. DOI: 10.1067/mai.2001.112124. View