Potential Mechanisms of Cancer Prevention and Treatment by Sulforaphane, a Natural Small Molecule Compound of Plant-derived

Overview

Journal Mol Med

Publisher Biomed Central

Specialties General Medicine
Molecular Biology

Date 2024 Jun 20

PMID 38902597

Authors

Pengtao Liu

Bo Zhang

Yuanqiang Li

Qipeng Yuan

Affiliations

Soon will be listed here.

Abstract

Despite recent advances in tumor diagnosis and treatment technologies, the number of cancer cases and deaths worldwide continues to increase yearly, creating an urgent need to find new methods to prevent or treat cancer. Sulforaphane (SFN), as a member of the isothiocyanates (ITCs) family, which is the hydrolysis product of glucosinolates (GLs), has been shown to have significant preventive and therapeutic cancer effects in different human cancers. Early studies have shown that SFN scavenges oxygen radicals by increasing cellular defenses against oxidative damage, mainly through the induction of phase II detoxification enzymes by nuclear factor erythroid 2-related factor 2 (Nrf2). More and more studies have shown that the anticancer mechanism of SFN also includes induction of apoptotic pathway in tumor cells, inhibition of cell cycle progression, and suppression of tumor stem cells. Therefore, the application of SFN is expected to be a necessary new approach to treating cancer. In this paper, we review the multiple molecular mechanisms of SFN in cancer prevention and treatment in recent years, which can provide a new vision for cancer treatment.

Citing Articles

Impact of Sulforaphane on Breast Cancer Progression and Radiation Therapy Outcomes: A Systematic Review.

Alhazmi N, Subahi A Cureus. 2025; 17(1):e78060.

PMID: 40013196 PMC: 11863992. DOI: 10.7759/cureus.78060.

References

Han S, Wang Z, Liu J, Wang H, Yuan Q . miR-29a-3p-dependent COL3A1 and COL5A1 expression reduction assists sulforaphane to inhibit gastric cancer progression. Biochem Pharmacol. 2021; 188:114539. DOI: 10.1016/j.bcp.2021.114539. View

Xu Y, Han X, Li Y, Min H, Zhao X, Zhang Y . Sulforaphane Mediates Glutathione Depletion via Polymeric Nanoparticles to Restore Cisplatin Chemosensitivity. ACS Nano. 2019; 13(11):13445-13455. DOI: 10.1021/acsnano.9b07032. View

Zhang Y, Gilmour A, Ahn Y, de la Vega L, Dinkova-Kostova A . The isothiocyanate sulforaphane inhibits mTOR in an NRF2-independent manner. Phytomedicine. 2019; 86:153062. PMC: 8106549. DOI: 10.1016/j.phymed.2019.153062. View

Negrette-Guzman M . Combinations of the antioxidants sulforaphane or curcumin and the conventional antineoplastics cisplatin or doxorubicin as prospects for anticancer chemotherapy. Eur J Pharmacol. 2019; 859:172513. DOI: 10.1016/j.ejphar.2019.172513. View

Royston K, Paul B, Nozell S, Rajbhandari R, Tollefsbol T . Withaferin A and sulforaphane regulate breast cancer cell cycle progression through epigenetic mechanisms. Exp Cell Res. 2018; 368(1):67-74. PMC: 6733260. DOI: 10.1016/j.yexcr.2018.04.015. View

Li J, Xu J, Sun Y, Fu R, Ye D . An Insight on Synergistic Anti-cancer Efficacy of Biochanin A and Sulforaphane Combination Against Breast Cancer. Appl Biochem Biotechnol. 2023; 196(2):992-1007. DOI: 10.1007/s12010-023-04584-w. View

Yepes-Molina L, Carvajal M . Nanoencapsulation of sulforaphane in broccoli membrane vesicles and their antiproliferative activity. Pharm Biol. 2021; 59(1):1490-1504. PMC: 8567929. DOI: 10.1080/13880209.2021.1992450. View

Peng X, Zhou Y, Tian H, Yang G, Li C, Geng Y . Sulforaphane inhibits invasion by phosphorylating ERK1/2 to regulate E-cadherin and CD44v6 in human prostate cancer DU145 cells. Oncol Rep. 2015; 34(3):1565-72. DOI: 10.3892/or.2015.4098. View

Liu Z, Zhang W, Phillips J, Arora R, McClellan S, Li J . Immunoregulatory protein B7-H3 regulates cancer stem cell enrichment and drug resistance through MVP-mediated MEK activation. Oncogene. 2018; 38(1):88-102. PMC: 6318029. DOI: 10.1038/s41388-018-0407-9. View

10.

Martin S, Kala R, Tollefsbol T . Mechanisms for the Inhibition of Colon Cancer Cells by Sulforaphane through Epigenetic Modulation of MicroRNA-21 and Human Telomerase Reverse Transcriptase (hTERT) Down-regulation. Curr Cancer Drug Targets. 2017; 18(1):97-106. PMC: 5577390. DOI: 10.2174/1568009617666170206104032. View

11.

Miao Z, Yu F, Ren Y, Yang J . d,l-Sulforaphane Induces ROS-Dependent Apoptosis in Human Gliomablastoma Cells by Inactivating STAT3 Signaling Pathway. Int J Mol Sci. 2017; 18(1). PMC: 5297707. DOI: 10.3390/ijms18010072. View

12.

Ahmad A, Nawaz M . Molecular mechanism of VEGF and its role in pathological angiogenesis. J Cell Biochem. 2022; 123(12):1938-1965. DOI: 10.1002/jcb.30344. View

13.

Yan Y, Xu Z, Dai S, Qian L, Sun L, Gong Z . Targeting autophagy to sensitive glioma to temozolomide treatment. J Exp Clin Cancer Res. 2016; 35:23. PMC: 4736617. DOI: 10.1186/s13046-016-0303-5. View

14.

Schell J, Wisidagama D, Bensard C, Zhao H, Wei P, Tanner J . Control of intestinal stem cell function and proliferation by mitochondrial pyruvate metabolism. Nat Cell Biol. 2017; 19(9):1027-1036. PMC: 6137334. DOI: 10.1038/ncb3593. View

15.

Bose C, Awasthi S, Sharma R, Benes H, Hauer-Jensen M, Boerma M . Sulforaphane potentiates anticancer effects of doxorubicin and attenuates its cardiotoxicity in a breast cancer model. PLoS One. 2018; 13(3):e0193918. PMC: 5843244. DOI: 10.1371/journal.pone.0193918. View

16.

Wen J, Yang F, Fang C, Chen H, Yang L . Sulforaphane triggers iron overload-mediated ferroptosis in gastric carcinoma cells by activating the PI3K/IRP2/DMT1 pathway. Hum Exp Toxicol. 2023; 42:9603271231177295. DOI: 10.1177/09603271231177295. View

17.

Zhu J, Wang S, Chen Y, Li X, Jiang Y, Yang X . miR-19 targeting of GSK3β mediates sulforaphane suppression of lung cancer stem cells. J Nutr Biochem. 2017; 44:80-91. DOI: 10.1016/j.jnutbio.2017.02.020. View

18.

Zhang Z, Li C, Shang L, Zhang Y, Zou R, Zhan Y . Sulforaphane induces apoptosis and inhibits invasion in U251MG glioblastoma cells. Springerplus. 2016; 5:235. PMC: 4771656. DOI: 10.1186/s40064-016-1910-5. View

19.

Bones A, Rossiter J . The enzymic and chemically induced decomposition of glucosinolates. Phytochemistry. 2006; 67(11):1053-67. DOI: 10.1016/j.phytochem.2006.02.024. View

20.

Wang F, Sun Y, Huang X, Qiao C, Zhang W, Liu P . Sulforaphane inhibits self-renewal of lung cancer stem cells through the modulation of sonic Hedgehog signaling pathway and polyhomeotic homolog 3. AMB Express. 2021; 11(1):121. PMC: 8382806. DOI: 10.1186/s13568-021-01281-x. View