Analysis of Pulmonary Microecology and Clinical Characteristics of Patients Carrying Human Herpesvirus

Overview

Journal Future Microbiol

Specialties Infectious Diseases
Microbiology

Date 2024 Jun 20

PMID 38899531

Authors

Jing Luo

Rui Xie

Chongxi Bao

Jinyan Lin

Yang Xu

Xuexin Yan

Zhen Yang

Li Feng

Jianing Wu

Dan Chen

Zaiqing He

Jinliang Kong

Affiliations

Soon will be listed here.

Abstract

To investigate the impact of human herpes virus () carriage on lung microbiota, and its correlation with clinical features and laboratory indicators in patients. Retrospective analysis was conducted on 30 outpatient lung infection cases, which were divided into (n = 15) and non- (n = 15) groups. mNGS detected microbial composition. Microbial diversity and abundance were tested using Shannon and Chao1 indices. Their relationship with laboratory indicators were explored. Significant differences in microbial abundance and distribution were found between two groups (p < 0.05). Moreover, HHV group showed negative correlations (p < 0.05) between , , and basophil/eosinophil percentages. carriage impacts lung microbiota, emphasizing the need for clinicians to pay attention to reactivation in outpatient lung infection patients.

References

Yuan X, Xie L, Shi Z, Zhou M . Application of mNGS in the study of pulmonary microbiome in pneumoconiosis complicated with pulmonary infection patients and exploration of potential biomarkers. Front Cell Infect Microbiol. 2023; 13:1200157. PMC: 10403237. DOI: 10.3389/fcimb.2023.1200157. View

dHumieres C, Salmona M, Delliere S, Leo S, Rodriguez C, Angebault C . The Potential Role of Clinical Metagenomics in Infectious Diseases: Therapeutic Perspectives. Drugs. 2021; 81(13):1453-1466. PMC: 8323086. DOI: 10.1007/s40265-021-01572-4. View

WARREN S, Carpenter C, BOAK R . SYMPTOMATIC HERPES, A SEQUELA OF ARTIFICIALLY INDUCED FEVER : INCIDENCE AND C ASPECTS; RECOVERY OF A VIRUS FROM HERPETIC VESICLES, AND COMPARISON WITH A K STRAIN OF HERPES VIRUS. J Exp Med. 2009; 71(2):155-68. PMC: 2135070. DOI: 10.1084/jem.71.2.155. View

Linssen C, Jacobs J, Stelma F, van Mook W, Terporten P, Vink C . Herpes simplex virus load in bronchoalveolar lavage fluid is related to poor outcome in critically ill patients. Intensive Care Med. 2008; 34(12):2202-9. DOI: 10.1007/s00134-008-1231-4. View

Simner P, Miller S, Carroll K . Understanding the Promises and Hurdles of Metagenomic Next-Generation Sequencing as a Diagnostic Tool for Infectious Diseases. Clin Infect Dis. 2017; 66(5):778-788. PMC: 7108102. DOI: 10.1093/cid/cix881. View

Gatto I, Biagioni E, Coloretti I, Farinelli C, Avoni C, Caciagli V . Cytomegalovirus blood reactivation in COVID-19 critically ill patients: risk factors and impact on mortality. Intensive Care Med. 2022; 48(6):706-713. PMC: 9116062. DOI: 10.1007/s00134-022-06716-y. View

Giacobbe D, Di Bella S, Lovecchio A, Ball L, De Maria A, Vena A . Herpes Simplex Virus 1 (HSV-1) Reactivation in Critically Ill COVID-19 Patients: A Brief Narrative Review. Infect Dis Ther. 2022; 11(5):1779-1791. PMC: 9340740. DOI: 10.1007/s40121-022-00674-0. View

Zhou W, Chen J, Xi Z, Shi Y, Wang L, Lu A . Characteristics of Lung Microbiota in Children's Refractory Pneumonia Coinfected with . Can J Infect Dis Med Microbiol. 2022; 2022:7065890. PMC: 8786547. DOI: 10.1155/2022/7065890. View

Meyer A, Buetti N, Houhou-Fidouh N, Patrier J, Abdel-Nabey M, Jaquet P . HSV-1 reactivation is associated with an increased risk of mortality and pneumonia in critically ill COVID-19 patients. Crit Care. 2021; 25(1):417. PMC: 8647503. DOI: 10.1186/s13054-021-03843-8. View

10.

Sawtell N, Thompson R . Rapid in vivo reactivation of herpes simplex virus in latently infected murine ganglionic neurons after transient hyperthermia. J Virol. 1992; 66(4):2150-6. PMC: 289007. DOI: 10.1128/JVI.66.4.2150-2156.1992. View

11.

Sekimukai H, Iwata-Yoshikawa N, Fukushi S, Tani H, Kataoka M, Suzuki T . Gold nanoparticle-adjuvanted S protein induces a strong antigen-specific IgG response against severe acute respiratory syndrome-related coronavirus infection, but fails to induce protective antibodies and limit eosinophilic infiltration in lungs. Microbiol Immunol. 2019; 64(1):33-51. PMC: 7168429. DOI: 10.1111/1348-0421.12754. View

12.

Tunney M, Einarsson G, Wei L, Drain M, Klem E, Cardwell C . Lung microbiota and bacterial abundance in patients with bronchiectasis when clinically stable and during exacerbation. Am J Respir Crit Care Med. 2013; 187(10):1118-26. PMC: 3734618. DOI: 10.1164/rccm.201210-1937OC. View

13.

Qian L, Shi Y, Li F, Wang Y, Ma M, Zhang Y . Metagenomic Next-Generation Sequencing of Cerebrospinal Fluid for the Diagnosis of External Ventricular and Lumbar Drainage-Associated Ventriculitis and Meningitis. Front Microbiol. 2020; 11:596175. PMC: 7767851. DOI: 10.3389/fmicb.2020.596175. View

14.

Moore M, Newcomb D, Parekh V, Van Kaer L, Collins R, Zhou W . STAT1 negatively regulates lung basophil IL-4 expression induced by respiratory syncytial virus infection. J Immunol. 2009; 183(3):2016-26. PMC: 3755459. DOI: 10.4049/jimmunol.0803167. View

15.

Papazian L, Hraiech S, Lehingue S, Roch A, Chiche L, Wiramus S . Cytomegalovirus reactivation in ICU patients. Intensive Care Med. 2015; 42(1):28-37. PMC: 7095171. DOI: 10.1007/s00134-015-4066-9. View

16.

Sathiyamoorthy K, Chen J, Longnecker R, Jardetzky T . The COMPLEXity in herpesvirus entry. Curr Opin Virol. 2017; 24:97-104. PMC: 8601108. DOI: 10.1016/j.coviro.2017.04.006. View

17.

Murdaca G, Di Gioacchino M, Greco M, Borro M, Paladin F, Petrarca C . Basophils and Mast Cells in COVID-19 Pathogenesis. Cells. 2021; 10(10). PMC: 8534912. DOI: 10.3390/cells10102754. View

18.

Leitao Filho F, Monica Peters C, Sheel A, Yang J, Nislow C, Lam S . Characterization of the Lower Airways and Oral Microbiota in Healthy Young Persons in the Community. Biomedicines. 2023; 11(3). PMC: 10045431. DOI: 10.3390/biomedicines11030841. View

19.

Libert N, Bigaillon C, Chargari C, Bensalah M, Muller V, Merat S . Epstein-Barr virus reactivation in critically ill immunocompetent patients. Biomed J. 2014; 38(1):70-6. DOI: 10.4103/2319-4170.132905. View

20.

Karasuyama H, Yamanishi Y . Basophils have emerged as a key player in immunity. Curr Opin Immunol. 2014; 31:1-7. DOI: 10.1016/j.coi.2014.07.004. View