Inter-continental Variability in the Relationship of Oxidative Potential and Cytotoxicity with PM Mass

Overview

Journal Nat Commun

Specialty Biology

Date 2024 Jun 19

PMID 38898130

Authors

Sudheer Salana

Haoran Yu

Zhuying Dai

P S Ganesh Subramanian

Joseph V Puthussery

Yixiang Wang

Ajit Singh

Francis D Pope

Manuel A Leiva G

Neeraj Rastogi

Sachchida Nand Tripathi

Rodney J Weber

Vishal Verma

Affiliations

Soon will be listed here.

Abstract

Most fine ambient particulate matter (PM)-based epidemiological models use globalized concentration-response (CR) functions assuming that the toxicity of PM is solely mass-dependent without considering its chemical composition. Although oxidative potential (OP) has emerged as an alternate metric of PM toxicity, the association between PM mass and OP on a large spatial extent has not been investigated. In this study, we evaluate this relationship using 385 PM samples collected from 14 different sites across 4 different continents and using 5 different OP (and cytotoxicity) endpoints. Our results show that the relationship between PM mass vs. OP (and cytotoxicity) is largely non-linear due to significant differences in the intrinsic toxicity, resulting from a spatially heterogeneous chemical composition of PM. These results emphasize the need to develop localized CR functions incorporating other measures of PM properties (e.g., OP) to better predict the PM-attributed health burdens.

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