New Insights Gained from Cellular Landscape Changes in Myocarditis and Inflammatory Cardiomyopathy

Overview

Journal Heart Fail Rev

Date 2024 Jun 19

PMID 38896377

Authors

Weiteng Wang

Hao Jia

Xiumeng Hua

Jiangping Song

Affiliations

Soon will be listed here.

Abstract

Advances in the etiological classification of myocarditis and inflammatory cardiomyopathy (ICM) have reached a consensus. However, the mechanism of myocarditis/ICM remains unclear, which affects the development of treatment and the improvement of outcome. Cellular transcription and metabolic reprogramming, and the interactions between cardiomyocytes and non-cardiomyocytes, such as the immune cells, contribute to the process of myocarditis/ICM. Recent efforts have been made by multi-omics techniques, particularly in single-cell RNA sequencing, to gain a better understanding of the cellular landscape alteration occurring in disease during the progression. This article aims to provide a comprehensive overview of the latest studies in myocarditis/ICM, particularly as revealed by single-cell sequencing.

Citing Articles

Lymphocytic Myocarditis in Children with Parvovirus B19 Infection: Pathological and Molecular Insights.

Pelzl L, Mantino S, Sauter M, Manuylova T, Vogel U, Klingel K Biomedicines. 2024; 12(8).

PMID: 39200373 PMC: 11352141. DOI: 10.3390/biomedicines12081909.

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