Ferroptosis: a New Mechanism of Traditional Chinese Medicine for Treating Ulcerative Colitis

Overview

Journal Front Pharmacol

Date 2024 Jun 19

PMID 38895617

Authors

Yingyi Wang

Yanwei Hao

Lingling Yuan

Huaie Tian

Xuhui Sun

Yi Zhang

Affiliations

Soon will be listed here.

Abstract

Aim Of The Review: This review summarizes the experimental studies on the targeted regulation of ferroptosis by TCM and its impact on UC in recent years, aiming to provide theoretical basis for the prevention, treatment, and further drug development for UC.

Results: Ferroptosis disrupts antioxidant mechanisms in intestinal epithelial cells, damages the intestinal mucosa, and participates in the pathological process of UC. TCM acts on various pathways such as / and GSH/GPX4, blocking the pathological progression of ferroptosis in intestinal epithelial cells, inhibiting pathological damage to the intestinal mucosa, and thereby alleviating UC.

Conclusion: The diverse array of TCM single herbs, extracts and herbal formulas facilitates selective and innovative research and development of new TCM methods for targeting UC treatment. Although progress has been made in studying TCM compound formulas, single herbs, and extracts, there are still many issues in clinical and basic experimental designs, necessitating further in-depth scientific exploration and research.

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