Human Papillomavirus Infection of the Oropharyngeal and Laryngeal Squamous Papilloma: Disparities in Prevalence and Characteristics

Overview

Journal Diagnostics (Basel)

Specialty Radiology

Date 2024 Jun 19

PMID 38893689

Authors

Jihye Kwak

Dongbin Ahn

Mee-Seon Kim

Affiliations

Soon will be listed here.

Abstract

Human papillomavirus (HPV) infection has emerged as an etiologic factor of squamous papilloma (SP). The oropharynx and larynx are common sites of SP, but studies on the prevalence of HPV infection in these sites are lacking. This study aimed to evaluate and compare the prevalence and characteristics of HPV infection in oropharyngeal SP (OPSP) and laryngeal SP (LSP). HPV detection and genotyping data of patients with pathologically confirmed OPSP and LSP were retrospectively analyzed. A total of 119 patients were enrolled, consisting of 93 patients with OPSP and 26 patients with LSP. Of those patients, 13 patients with OPSP and 14 patients with LSP were positive for HPV infection, accounting for a prevalence of 14.0% and 53.8%, respectively ( < 0.001). The most prevalent genotype was HPV16 in OPSP and HPV6 in LSP. Over two-thirds (69.2%) of HPV(+)-OPSP infections were high-risk types compared with 14.3% of HPV(+)-LSP infections ( = 0.004). The prevalence of HPV infection in patients with OPSP and LSP demonstrated no differences in terms of age, sex, and smoking status. These results could provide a better understanding of HPV infection in OPSP and LSP and serve as a background for the epidemiology of HPV-related tumorigenesis of the oropharynx and larynx.

References

Orita Y, Gion Y, Tachibana T, Ikegami K, Marunaka H, Makihara S . Laryngeal squamous cell papilloma is highly associated with human papillomavirus. Jpn J Clin Oncol. 2018; 48(4):350-355. DOI: 10.1093/jjco/hyy009. View

Doorbar J, Egawa N, Griffin H, Kranjec C, Murakami I . Human papillomavirus molecular biology and disease association. Rev Med Virol. 2015; 25 Suppl 1:2-23. PMC: 5024016. DOI: 10.1002/rmv.1822. View

Egawa N, Egawa K, Griffin H, Doorbar J . Human Papillomaviruses; Epithelial Tropisms, and the Development of Neoplasia. Viruses. 2015; 7(7):3863-90. PMC: 4517131. DOI: 10.3390/v7072802. View

Tommasino M . The human papillomavirus family and its role in carcinogenesis. Semin Cancer Biol. 2013; 26:13-21. DOI: 10.1016/j.semcancer.2013.11.002. View

Castellsague X, Alemany L, Quer M, Halec G, Quiros B, Tous S . HPV Involvement in Head and Neck Cancers: Comprehensive Assessment of Biomarkers in 3680 Patients. J Natl Cancer Inst. 2016; 108(6):djv403. DOI: 10.1093/jnci/djv403. View

Kreimer A, Pierce Campbell C, Lin H, Fulp W, Papenfuss M, Abrahamsen M . Incidence and clearance of oral human papillomavirus infection in men: the HIM cohort study. Lancet. 2013; 382(9895):877-87. PMC: 3904652. DOI: 10.1016/S0140-6736(13)60809-0. View

Kurita T, Chitose S, Sato K, Sakazaki T, Fukahori M, Sueyoshi S . Pathological mechanisms of laryngeal papillomatosis based on laryngeal epithelial characteristics. Laryngoscope Investig Otolaryngol. 2019; 4(1):89-94. PMC: 6383308. DOI: 10.1002/lio2.242. View

Torrente M, Rodrigo J, Haigentz Jr M, Dikkers F, Rinaldo A, Takes R . Human papillomavirus infections in laryngeal cancer. Head Neck. 2010; 33(4):581-6. DOI: 10.1002/hed.21421. View

Gillison M, Broutian T, Pickard R, Tong Z, Xiao W, Kahle L . Prevalence of oral HPV infection in the United States, 2009-2010. JAMA. 2012; 307(7):693-703. PMC: 5790188. DOI: 10.1001/jama.2012.101. View

10.

Fortes H, von Ranke F, Escuissato D, Araujo Neto C, Zanetti G, Hochhegger B . Recurrent respiratory papillomatosis: A state-of-the-art review. Respir Med. 2017; 126:116-121. DOI: 10.1016/j.rmed.2017.03.030. View

11.

Ahn D, Heo S, Lee G, Sohn J, Jeong J . Prevalence and characteristics of tonsillar human papillomavirus infection in tumor-free patients undergoing tonsillectomy. Auris Nasus Larynx. 2021; 49(2):229-234. DOI: 10.1016/j.anl.2021.07.011. View

12.

Wierzbicka M, Klussmann J, San Giorgi M, Wuerdemann N, Dikkers F . Oral and laryngeal HPV infection: Incidence, prevalence and risk factors, with special regard to concurrent infection in head, neck and genitals. Vaccine. 2021; 39(17):2344-2350. DOI: 10.1016/j.vaccine.2021.03.047. View

13.

You E, Henry M, Zeitouni A . Human papillomavirus-associated oropharyngeal cancer: review of current evidence and management. Curr Oncol. 2019; 26(2):119-123. PMC: 6476447. DOI: 10.3747/co.26.4819. View

14.

Hirai R, Makiyama K, Higuti Y, Ikeda A, Miura M, Hasegawa H . Pharyngeal squamous cell papilloma in adult Japanese: comparison with laryngeal papilloma in clinical manifestations and HPV infection. Eur Arch Otorhinolaryngol. 2012; 269(10):2271-6. DOI: 10.1007/s00405-011-1908-0. View

15.

Mehanna H, Taberna M, von Buchwald C, Tous S, Brooks J, Mena M . Prognostic implications of p16 and HPV discordance in oropharyngeal cancer (HNCIG-EPIC-OPC): a multicentre, multinational, individual patient data analysis. Lancet Oncol. 2023; 24(3):239-251. DOI: 10.1016/S1470-2045(23)00013-X. View

16.

Gheit T, Muwonge R, Lucas E, Galati L, Anantharaman D, McKay-Chopin S . Impact of HPV vaccination on HPV-related oral infections. Oral Oncol. 2022; 136:106244. PMC: 9833124. DOI: 10.1016/j.oraloncology.2022.106244. View

17.

Omland T, Lie K, Akre H, Sandlie L, Jebsen P, Sandvik L . Recurrent respiratory papillomatosis: HPV genotypes and risk of high-grade laryngeal neoplasia. PLoS One. 2014; 9(6):e99114. PMC: 4053369. DOI: 10.1371/journal.pone.0099114. View

18.

CROISSANT O, Breitburd F, Orth G . Specificity of cytopathic effect of cutaneous human papillomaviruses. Clin Dermatol. 1985; 3(4):43-55. DOI: 10.1016/0738-081x(85)90048-3. View

19.

Wojtera M, Paradis J, Husein M, Nichols A, Barrett J, Salvadori M . The prevalence of human papillomavirus in pediatric tonsils: a systematic review of the literature. J Otolaryngol Head Neck Surg. 2018; 47(1):8. PMC: 5789580. DOI: 10.1186/s40463-018-0255-1. View

20.

Gooi Z, Chan J, Fakhry C . The epidemiology of the human papillomavirus related to oropharyngeal head and neck cancer. Laryngoscope. 2016; 126(4):894-900. DOI: 10.1002/lary.25767. View