Impact of the SARS-CoV-2 (COVID-19) Pandemic on Characteristics and Management of Uveal Melanoma in the National Referral Center in Poland

Overview

Journal Cancers (Basel)

Publisher MDPI

Specialty Oncology

Date 2024 Jun 19

PMID 38893180

Authors

Bozena Romanowska-Dixon

Michal Szymon Nowak

Janusz Smigielski

Magdalena Debicka-Kumela

Affiliations

Soon will be listed here.

Abstract

(1) Background: to analyze the impact of the COVID-19 pandemic on the characteristics and management of uveal melanoma (UM) in the National Referral Center in Poland. (2) Materials and Methods: the retrospective analysis of 1336 patients who were newly diagnosed with UM at the Department of Ophthalmology and Ophthalmic Oncology, Jagiellonian University Collegium Medicum Krakow, Poland between 1 January 2018 and 31 December 2021. The demographic and clinical data were compiled, including localization, size, and treatment methods of tumors. (3) Results: In total, 728 patients with UM were included before the COVID-19 pandemic, in the years 2018-2019, and 608 were included during the COVID-19 pandemic, in the years 2020-2021. Fixed-base dynamics indicators for the incidence of uveal melanoma (base year 2018) in the National Referral Center in Poland were 80.22% and 86.81% in the years 2020 and 2021, respectively. UMs were statistically significantly larger and more frequently localized anterior to the equator of the eye globe in the year 2021 than in the year 2018 (Chi-square Pearson test = 0.0001 and = 0.0077, respectively). The rate of patients treated with enucleation increased from 15.94% in the year 2018 to 26.90% in the year 2021 (Chi-square Pearson test = 0.0005). (4) Conclusions: Statistically significant differences were found in the management of uveal melanoma in the National Referral Center in Poland during the COVID-19 pandemic with tumors being larger, more frequently localized anterior to the equator of the eye globe, and more often enucleated.

References

Virgili G, Gatta G, Ciccolallo L, Capocaccia R, Biggeri A, Crocetti E . Incidence of uveal melanoma in Europe. Ophthalmology. 2007; 114(12):2309-15. DOI: 10.1016/j.ophtha.2007.01.032. View

Aronow M, Topham A, Singh A . Uveal Melanoma: 5-Year Update on Incidence, Treatment, and Survival (SEER 1973-2013). Ocul Oncol Pathol. 2018; 4(3):145-151. PMC: 5939716. DOI: 10.1159/000480640. View

Nowak M, Romanowska-Dixon B, Grabska-Liberek I, Zurek M . Incidence and Characteristics of Retinoblastoma in Poland: The First Nationwide Study 2010-2017. Int J Environ Res Public Health. 2021; 18(12). PMC: 8296438. DOI: 10.3390/ijerph18126539. View

Wang H, Elsheikh M, Gilmour K, Cohen V, Sagoo M, Damato B . Impact of COVID-19 pandemic on eye cancer care in United Kingdom. Br J Cancer. 2021; 124(8):1357-1360. PMC: 8039025. DOI: 10.1038/s41416-021-01274-4. View

Romanowska-Dixon B, Debicka-Kumela M, Smigielski J, Nowak M . Sex Differences in the Treatment of Uveal Melanoma in a Group of 1336 Patients. J Pers Med. 2023; 13(2). PMC: 9967634. DOI: 10.3390/jpm13020353. View

Hasegawa N, Rusakevich A, Bernicker E, Teh B, Schefler A . Comparison of Tumor Size and Gene Expression at Presentation in Uveal Melanoma Patients before and during the COVID-19 Pandemic. Ocul Oncol Pathol. 2023; 8(3):156-160. PMC: 9372456. DOI: 10.1159/000524918. View

Tan L, Hong J, Goh W, Chang E, Yang V, Poon E . Clinical features and survival outcomes of ocular melanoma in a multi-ethnic Asian cohort. Sci Rep. 2020; 10(1):16367. PMC: 7529790. DOI: 10.1038/s41598-020-73534-x. View

Wu P, Duan F, Luo C, Liu Q, Qu X, Liang L . Characteristics of Ocular Findings of Patients With Coronavirus Disease 2019 (COVID-19) in Hubei Province, China. JAMA Ophthalmol. 2020; 138(5):575-578. PMC: 7110919. DOI: 10.1001/jamaophthalmol.2020.1291. View

Kanclerz P, Lanca C, Radomski S, Nowak M . The outdoor time in non-myopic children has decreased to that of myopic children during the SARS-CoV-2 pandemic. Rom J Ophthalmol. 2023; 67(1):33-40. PMC: 10117183. DOI: 10.22336/rjo.2023.6. View

10.

Jovanovic P, Mihajlovic M, Djordjevic-Jocic J, Vlajkovic S, Cekic S, Stefanovic V . Ocular melanoma: an overview of the current status. Int J Clin Exp Pathol. 2013; 6(7):1230-44. PMC: 3693189. View

11.

Bermudez-Castellanos I, Saornil Alvarez M, Almaraz Gomez A, Villoria-Diaz S, Garcia Alvarez C . Impact of COVID-19 on a rare disease (uveal melanoma) in a national reference unit of intraocular tumors in Spain. Arch Soc Esp Oftalmol (Engl Ed). 2023; 98(5):254-258. PMC: 10110274. DOI: 10.1016/j.oftale.2023.04.007. View

12.

Park S, Oh C, Kim B, Woo S, Cho H, Park K . Nationwide Incidence of Ocular Melanoma in South Korea by Using the National Cancer Registry Database (1999-2011). Invest Ophthalmol Vis Sci. 2015; 56(8):4719-24. DOI: 10.1167/iovs.15-16532. View

13.

Rajeshuni N, Zubair T, Ludwig C, Moshfeghi D, Mruthyunjaya P . Evaluation of Racial, Ethnic, and Socioeconomic Associations With Treatment and Survival in Uveal Melanoma, 2004-2014. JAMA Ophthalmol. 2020; 138(8):876-884. PMC: 7333178. DOI: 10.1001/jamaophthalmol.2020.2254. View

14.

Ortega M, Fraile-Martinez O, Garcia-Honduvilla N, Coca S, Alvarez-Mon M, Bujan J . Update on uveal melanoma: Translational research from biology to clinical practice (Review). Int J Oncol. 2020; 57(6):1262-1279. PMC: 7646582. DOI: 10.3892/ijo.2020.5140. View

15.

Nowak M, Romanowska-Dixon B, Grabska-Liberek I, Zurek M . Incidence and survival of ocular melanoma in National Cancer Registry of Poland in 2010-2017. Adv Clin Exp Med. 2022; 31(6):615-621. DOI: 10.17219/acem/146581. View

16.

Manjandavida F, Honavar S, Kim U, Singh U, Menon V, Das S . Ocular oncology practice guidelines during COVID-19 pandemic-An expert consensus. Indian J Ophthalmol. 2020; 68(7):1281-1291. PMC: 7574098. DOI: 10.4103/ijo.IJO_1669_20. View

17.

Dolar-Szczasny J, Toro M, Dworzanska A, Wojtowicz T, Korona-Glowniak I, Sawicki R . Ocular Involvement of SARS-CoV-2 in a Polish Cohort of COVID-19-Positive Patients. Int J Environ Res Public Health. 2021; 18(6). PMC: 8001647. DOI: 10.3390/ijerph18062916. View

18.

Xu Y, Lou L, Wang Y, Miao Q, Jin K, Chen M . Epidemiological Study of Uveal Melanoma from US Surveillance, Epidemiology, and End Results Program (2010-2015). J Ophthalmol. 2020; 2020:3614039. PMC: 7049826. DOI: 10.1155/2020/3614039. View

19.

Ledford S, Kessler F, Moss J, Wang M, Lengerich E . The Impact of the COVID-19 Pandemic on Cancer Mortality in Pennsylvania: A Retrospective Study with Geospatial Analysis. Cancers (Basel). 2023; 15(19). PMC: 10571537. DOI: 10.3390/cancers15194788. View

20.

Frenkel S, Hendler K, Peer J . Uveal melanoma in Israel in the last two decades: characterization, treatment and prognosis. Isr Med Assoc J. 2009; 11(5):280-5. View