A Cross Talking Between the Gut Microbiota and Metabolites of Participants in a Confined Environment

Overview

Journal Nutrients

Date 2024 Jun 19

PMID 38892694

Authors

Xin Song

Ziying Wang

Yongjun Xia

Zheng Chen

Guangqiang Wang

Yijin Yang

Beiwei Zhu

Lianzhong Ai

Haodan Xu

Chuan Wang

Affiliations

Soon will be listed here.

Abstract

Certain workplaces, like deep-sea voyages, subject workers to chronic psychological stress and circadian rhythm disorders due to confined environments and frequent shifts. In this study, participants lived in a strictly controlled confined environment, and we analyzed the effects of a confined environment on gut microbiota and metabolites. The results showed that living in confined environments can significantly alter both the gut microbiota and the gut metabolome, particularly affecting lipid metabolism pathways like glycerophospholipid metabolism. There was a significant reduction in the abundance of and , while , , and showed significant increases. An association analysis revealed a strong correlation between changes in the gut microbiota and the metabolome. Four upregulated lipid metabolites may serve as biomarkers for damage induced by confined environments, and certain gut microbiota alterations, such as those involving and , could be potential psychobiotics or therapeutic targets for enhancing mental health in a confined environment.

References

Choi H, Rao M, Chang E . Gut microbiota as a transducer of dietary cues to regulate host circadian rhythms and metabolism. Nat Rev Gastroenterol Hepatol. 2021; 18(10):679-689. PMC: 8521648. DOI: 10.1038/s41575-021-00452-2. View

Wang N, Sun Y, Zhang H, Wang B, Chen C, Wang Y . Long-term night shift work is associated with the risk of atrial fibrillation and coronary heart disease. Eur Heart J. 2021; 42(40):4180-4188. DOI: 10.1093/eurheartj/ehab505. View

Astbury S, Atallah E, Vijay A, Aithal G, Grove J, Valdes A . Lower gut microbiome diversity and higher abundance of proinflammatory genus are associated with biopsy-proven nonalcoholic steatohepatitis. Gut Microbes. 2019; 11(3):569-580. PMC: 7524262. DOI: 10.1080/19490976.2019.1681861. View

Lopez-Santamarina A, Mondragon A, Cardelle-Cobas A, Santos E, Porto-Arias J, Cepeda A . Effects of Unconventional Work and Shift Work on the Human Gut Microbiota and the Potential of Probiotics to Restore Dysbiosis. Nutrients. 2023; 15(13). PMC: 10346351. DOI: 10.3390/nu15133070. View

Qian J, Vujovic N, Nguyen H, Rahman N, Heng S, Amira S . Daytime eating prevents mood vulnerability in night work. Proc Natl Acad Sci U S A. 2022; 119(38):e2206348119. PMC: 9499546. DOI: 10.1073/pnas.2206348119. View

Grabauskas G, Wu X, Gao J, Li J, Turgeon D, Owyang C . Prostaglandin E, Produced by Mast Cells in Colon Tissues From Patients With Irritable Bowel Syndrome, Contributes to Visceral Hypersensitivity in Mice. Gastroenterology. 2020; 158(8):2195-2207.e6. PMC: 7282934. DOI: 10.1053/j.gastro.2020.02.022. View

Li L, Su Q, Xie B, Duan L, Zhao W, Hu D . Gut microbes in correlation with mood: case study in a closed experimental human life support system. Neurogastroenterol Motil. 2016; 28(8):1233-40. DOI: 10.1111/nmo.12822. View

Lambeth S, Carson T, Lowe J, Ramaraj T, Leff J, Luo L . Composition, Diversity and Abundance of Gut Microbiome in Prediabetes and Type 2 Diabetes. J Diabetes Obes. 2016; 2(3):1-7. PMC: 4705851. DOI: 10.15436/2376-0949.15.031. View

Ruiz-Limon P, Mena-Vazquez N, Moreno-Indias I, Manrique-Arija S, Lisbona-Montanez J, Cano-Garcia L . Collinsella is associated with cumulative inflammatory burden in an established rheumatoid arthritis cohort. Biomed Pharmacother. 2022; 153:113518. DOI: 10.1016/j.biopha.2022.113518. View

10.

Mackos A, Varaljay V, Maltz R, Gur T, Bailey M . Role of the Intestinal Microbiota in Host Responses to Stressor Exposure. Int Rev Neurobiol. 2016; 131:1-19. DOI: 10.1016/bs.irn.2016.08.002. View

11.

Liang X, Bushman F, FitzGerald G . Rhythmicity of the intestinal microbiota is regulated by gender and the host circadian clock. Proc Natl Acad Sci U S A. 2015; 112(33):10479-84. PMC: 4547234. DOI: 10.1073/pnas.1501305112. View

12.

Bijnens S, Depoortere I . Controlled light exposure and intermittent fasting as treatment strategies for metabolic syndrome and gut microbiome dysregulation in night shift workers. Physiol Behav. 2023; 263:114103. DOI: 10.1016/j.physbeh.2023.114103. View

13.

Grosicki G, Riemann B, Flatt A, Valentino T, Lustgarten M . Self-reported sleep quality is associated with gut microbiome composition in young, healthy individuals: a pilot study. Sleep Med. 2020; 73:76-81. PMC: 7487045. DOI: 10.1016/j.sleep.2020.04.013. View

14.

Lu Z, Liu Y, Ji Z, Fu T, Yan M, Shao Z . Alterations in the intestinal microbiome and mental health status of workers in an underground tunnel environment. BMC Microbiol. 2021; 21(1):7. PMC: 7788853. DOI: 10.1186/s12866-020-02056-3. View

15.

Li W, Wang Z, Cao J, Dong Y, Chen Y . Melatonin improves skin barrier damage caused by sleep restriction through gut microbiota. J Pineal Res. 2023; 75(1):e12874. DOI: 10.1111/jpi.12874. View

16.

Guido M, Monjes N, Wagner P, Salvador G . Circadian Regulation and Clock-Controlled Mechanisms of Glycerophospholipid Metabolism from Neuronal Cells and Tissues to Fibroblasts. Mol Neurobiol. 2021; 59(1):326-353. DOI: 10.1007/s12035-021-02595-4. View

17.

Evans S, Bassis C, Hein R, Assari S, Flowers S, Kelly M . The gut microbiome composition associates with bipolar disorder and illness severity. J Psychiatr Res. 2016; 87:23-29. PMC: 5336480. DOI: 10.1016/j.jpsychires.2016.12.007. View

18.

Mortas H, Bilici S, Karakan T . The circadian disruption of night work alters gut microbiota consistent with elevated risk for future metabolic and gastrointestinal pathology. Chronobiol Int. 2020; 37(7):1067-1081. DOI: 10.1080/07420528.2020.1778717. View

19.

Tian Y, Yang W, Chen G, Men C, Gu Y, Song X . An important link between the gut microbiota and the circadian rhythm: imply for treatments of circadian rhythm sleep disorder. Food Sci Biotechnol. 2022; 31(2):155-164. PMC: 8817960. DOI: 10.1007/s10068-021-01015-6. View

20.

Zhang Y, Fan Q, Hou Y, Zhang X, Yin Z, Cai X . Bacteroides species differentially modulate depression-like behavior via gut-brain metabolic signaling. Brain Behav Immun. 2022; 102:11-22. DOI: 10.1016/j.bbi.2022.02.007. View