The Molecular Key to Understanding the Medical Ozone Action

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2024 Jun 19

PMID 38892336

Authors

Lamberto Re

Affiliations

Soon will be listed here.

Abstract

Currently, treatment with medical ozone (MO) is considered one of the most interesting and safe integrative options that can effectively complement many conventional medical therapies, mainly, but not exclusively, involving aging and pain [...].

References

Bocci V, Zanardi I, Huijberts M, Travagli V . An integrated medical treatment for type-2 diabetes. Diabetes Metab Syndr. 2014; 8(1):57-61. DOI: 10.1016/j.dsx.2013.10.004. View

McCord J, Gao B, Hybertson B . The Complex Genetic and Epigenetic Regulation of the Nrf2 Pathways: A Review. Antioxidants (Basel). 2023; 12(2). PMC: 9952775. DOI: 10.3390/antiox12020366. View

Bischoff L, Kuijper I, Schimming J, Wolters L, Ter Braak B, Langenberg J . A systematic analysis of Nrf2 pathway activation dynamics during repeated xenobiotic exposure. Arch Toxicol. 2018; 93(2):435-451. DOI: 10.1007/s00204-018-2353-2. View

Re L . Ozone in Medicine: A Few Points of Reflections. Front Physiol. 2022; 13:842229. PMC: 8905360. DOI: 10.3389/fphys.2022.842229. View

Zhu F, Ding S, Liu Y, Wang X, Wu Z . Ozone-mediated cerebral protection: Unraveling the mechanism through ferroptosis and the NRF2/SLC7A11/GPX4 signaling pathway. J Chem Neuroanat. 2024; 136:102387. DOI: 10.1016/j.jchemneu.2023.102387. View

Braidy N, Izadi M, Sureda A, Jonaidi-Jafari N, Banki A, Nabavi S . Therapeutic relevance of ozone therapy in degenerative diseases: Focus on diabetes and spinal pain. J Cell Physiol. 2017; 233(4):2705-2714. DOI: 10.1002/jcp.26044. View

. Global age-sex-specific mortality, life expectancy, and population estimates in 204 countries and territories and 811 subnational locations, 1950-2021, and the impact of the COVID-19 pandemic: a comprehensive demographic analysis for the Global.... Lancet. 2024; 403(10440):1989-2056. PMC: 11126395. DOI: 10.1016/S0140-6736(24)00476-8. View

Scassellati C, Ciani M, Carlo Galoforo A, Zanardini R, Bonvicini C, Geroldi C . Molecular mechanisms in cognitive frailty: potential therapeutic targets for oxygen-ozone treatment. Mech Ageing Dev. 2020; 186:111210. DOI: 10.1016/j.mad.2020.111210. View

Zeng D, Yin C, Wei H, Li Y, Yang Y, Nie H . Activation of Nrf2 antioxidant signaling alleviates gout arthritis pain and inflammation. Biomed Pharmacother. 2023; 170:115957. DOI: 10.1016/j.biopha.2023.115957. View

10.

Inguscio C, Dalla Pozza E, Dando I, Boschi F, Tabaracci G, Angelini O . Mitochondrial Features of Mouse Myoblasts Are Finely Tuned by Low Doses of Ozone: The Evidence In Vitro. Int J Mol Sci. 2023; 24(10). PMC: 10218946. DOI: 10.3390/ijms24108900. View

11.

Re L, Martinez-Sanchez G, Bordicchia M, Malcangi G, Pocognoli A, Morales-Segura M . Is ozone pre-conditioning effect linked to Nrf2/EpRE activation pathway in vivo? A preliminary result. Eur J Pharmacol. 2014; 742:158-62. DOI: 10.1016/j.ejphar.2014.08.029. View

12.

He F, Ru X, Wen T . NRF2, a Transcription Factor for Stress Response and Beyond. Int J Mol Sci. 2020; 21(13). PMC: 7369905. DOI: 10.3390/ijms21134777. View

13.

Hybertson B, Gao B, Bose S, McCord J . Oxidative stress in health and disease: the therapeutic potential of Nrf2 activation. Mol Aspects Med. 2011; 32(4-6):234-46. DOI: 10.1016/j.mam.2011.10.006. View

14.

Cuadrado A, Manda G, Hassan A, Alcaraz M, Barbas C, Daiber A . Transcription Factor NRF2 as a Therapeutic Target for Chronic Diseases: A Systems Medicine Approach. Pharmacol Rev. 2018; 70(2):348-383. DOI: 10.1124/pr.117.014753. View

15.

Sagai M, Bocci V . Mechanisms of Action Involved in Ozone Therapy: Is healing induced via a mild oxidative stress?. Med Gas Res. 2011; 1:29. PMC: 3298518. DOI: 10.1186/2045-9912-1-29. View

16.

Pecorelli A, Bocci V, Acquaviva A, Belmonte G, Gardi C, Virgili F . NRF2 activation is involved in ozonated human serum upregulation of HO-1 in endothelial cells. Toxicol Appl Pharmacol. 2012; 267(1):30-40. DOI: 10.1016/j.taap.2012.12.001. View

17.

Cuadrado A, Rojo A, Wells G, Hayes J, Cousin S, Rumsey W . Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases. Nat Rev Drug Discov. 2019; 18(4):295-317. DOI: 10.1038/s41573-018-0008-x. View

18.

Clavo B, Borrelli E . Editorial: Ozone in medicine: Biochemical background, physiological modulation and clinical applications. Front Physiol. 2023; 14:1112860. PMC: 9939878. DOI: 10.3389/fphys.2023.1112860. View

19.

Scassellati C, Carlo Galoforo A, Bonvicini C, Esposito C, Ricevuti G . Ozone: a natural bioactive molecule with antioxidant property as potential new strategy in aging and in neurodegenerative disorders. Ageing Res Rev. 2020; 63:101138. PMC: 7428719. DOI: 10.1016/j.arr.2020.101138. View