GDF15, an Emerging Player in Renal Physiology and Pathophysiology

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2024 Jun 19

PMID 38892145

Authors

Samia Lasaad

Gilles Crambert

Affiliations

Soon will be listed here.

Abstract

These last years, the growth factor GDF15 has emerged as a key element in many different biological processes. It has been established as being produced in response to many pathological states and is now referred to as a stress-related hormone. Regarding kidney functions, GDF15 has been involved in different pathologies such as chronic kidney disease, diabetic nephropathy, renal cancer, and so on. Interestingly, recent studies also revealed a role of GDF15 in the renal homeostatic mechanisms allowing to maintain constant, as far as possible, the plasma parameters such as pH and K values. In this review, we recapitulate the role of GDF15 in physiological and pathological context by focusing our interest on its renal effect.

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