Molecular Aspects of Cardiometabolic Diseases: From Etiopathogenesis to Potential Therapeutic Targets

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2024 Jun 19

PMID 38892029

Authors

Iveta Bernatova

Monika Bartekova

Affiliations

Soon will be listed here.

Abstract

Cardiometabolic diseases (CMDs) encompass a range of prevalent, often preventable, non-communicable illnesses, including myocardial infarction, stroke, cardiac insufficiency, arterial hypertension, obesity, type 2 diabetes mellitus, insulin resistance, chronic renal dysfunction, non-alcoholic fatty liver disease, and rare metabolic disorders [...].

References

Dynka D, Kowalcze K, Charuta A, Paziewska A . Reply to Najjar, R.S. Comment on "Dyńka et al. The Ketogenic Diet and Cardiovascular Diseases. 2023, , 3368". Nutrients. 2023; 15(20). PMC: 10609625. DOI: 10.3390/nu15204312. View

Mathews A, Famodu O, Olfert M, Murray P, Cuff C, Downes M . Efficacy of nutritional interventions to lower circulating ceramides in young adults: FRUVEDomic pilot study. Physiol Rep. 2017; 5(13). PMC: 5506522. DOI: 10.14814/phy2.13329. View

Li Y, Zhu M, Liu Y, Luo B, Cui J, Huang L . The oral microbiota and cardiometabolic health: A comprehensive review and emerging insights. Front Immunol. 2022; 13:1010368. PMC: 9716288. DOI: 10.3389/fimmu.2022.1010368. View

Wang W, Liu Y, Li Y, Luo B, Lin Z, Chen K . Dietary patterns and cardiometabolic health: Clinical evidence and mechanism. MedComm (2020). 2023; 4(1):e212. PMC: 9899878. DOI: 10.1002/mco2.212. View

. Height and body-mass index trajectories of school-aged children and adolescents from 1985 to 2019 in 200 countries and territories: a pooled analysis of 2181 population-based studies with 65 million participants. Lancet. 2020; 396(10261):1511-1524. PMC: 7658740. DOI: 10.1016/S0140-6736(20)31859-6. View

Belanger M, Rao P, Robbins J . Exercise, Physical Activity, and Cardiometabolic Health: Pathophysiologic Insights. Cardiol Rev. 2021; 30(3):134-144. PMC: 9097788. DOI: 10.1097/CRD.0000000000000417. View

Mirabito Colafella K, Bovee D, Danser A . The renin-angiotensin-aldosterone system and its therapeutic targets. Exp Eye Res. 2019; 186:107680. DOI: 10.1016/j.exer.2019.05.020. View

Koliaki C, Dalamaga M, Liatis S . Update on the Obesity Epidemic: After the Sudden Rise, Is the Upward Trajectory Beginning to Flatten?. Curr Obes Rep. 2023; 12(4):514-527. DOI: 10.1007/s13679-023-00527-y. View

Guo Y, Liu X, Li T, Zhao J, Yang Y, Yao Y . Alternate-Day Ketogenic Diet Feeding Protects against Heart Failure through Preservation of Ketogenesis in the Liver. Oxid Med Cell Longev. 2022; 2022:4253651. PMC: 9192193. DOI: 10.1155/2022/4253651. View

10.

Diab A, Dastmalchi L, Gulati M, Michos E . A Heart-Healthy Diet for Cardiovascular Disease Prevention: Where Are We Now?. Vasc Health Risk Manag. 2023; 19:237-253. PMC: 10128075. DOI: 10.2147/VHRM.S379874. View

11.

. Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants. Lancet. 2021; 398(10304):957-980. PMC: 8446938. DOI: 10.1016/S0140-6736(21)01330-1. View

12.

Dupas T, Pele T, Dhot J, Burban M, Persello A, Aillerie V . The Endothelial Dysfunction Could Be a Cause of Heart Failure with Preserved Ejection Fraction Development in a Rat Model. Oxid Med Cell Longev. 2022; 2022:7377877. PMC: 9132705. DOI: 10.1155/2022/7377877. View

13.

Sun H, Hou B, Wang X, Zhu X, Li K, Qiu L . Endothelial dysfunction and cardiometabolic diseases: Role of long non-coding RNAs. Life Sci. 2016; 167:6-11. DOI: 10.1016/j.lfs.2016.11.005. View

14.

Li C, Reif M, Craige S, Kant S, Keaney Jr J . Endothelial AMPK activation induces mitochondrial biogenesis and stress adaptation via eNOS-dependent mTORC1 signaling. Nitric Oxide. 2016; 55-56:45-53. PMC: 4860108. DOI: 10.1016/j.niox.2016.03.003. View

15.

Aksentijevich M, Lateef S, Anzenberg P, Dey A, Mehta N . Chronic inflammation, cardiometabolic diseases and effects of treatment: Psoriasis as a human model. Trends Cardiovasc Med. 2019; 30(8):472-478. PMC: 7428846. DOI: 10.1016/j.tcm.2019.11.001. View

16.

Chun L, Junlin Z, Aimin W, Niansheng L, Benmei C, Minxiang L . Inhibition of ceramide synthesis reverses endothelial dysfunction and atherosclerosis in streptozotocin-induced diabetic rats. Diabetes Res Clin Pract. 2011; 93(1):77-85. DOI: 10.1016/j.diabres.2011.03.017. View

17.

Karwi Q, Biswas D, Pulinilkunnil T, Lopaschuk G . Myocardial Ketones Metabolism in Heart Failure. J Card Fail. 2020; 26(11):998-1005. DOI: 10.1016/j.cardfail.2020.04.005. View

18.

Heitzer T, Baldus S, von Kodolitsch Y, Rudolph V, Meinertz T . Systemic endothelial dysfunction as an early predictor of adverse outcome in heart failure. Arterioscler Thromb Vasc Biol. 2005; 25(6):1174-9. DOI: 10.1161/01.ATV.0000166516.52477.81. View

19.

Klisic A, Kavaric N, Ninic A, Kotur-Stevuljevic J . Oxidative stress and cardiometabolic biomarkers in patients with non-alcoholic fatty liver disease. Sci Rep. 2021; 11(1):18455. PMC: 8445952. DOI: 10.1038/s41598-021-97686-6. View

20.

Nakamura M, Odanovic N, Nakada Y, Dohi S, Zhai P, Ivessa A . Dietary carbohydrates restriction inhibits the development of cardiac hypertrophy and heart failure. Cardiovasc Res. 2020; 117(11):2365-2376. PMC: 8861266. DOI: 10.1093/cvr/cvaa298. View