Investigation of Alveolar Osteitis and the Effectiveness of Laser Treatment: a Unified Meta-analysis and Review of the Literature

Overview

Journal BMC Oral Health

Publisher Biomed Central

Specialty Dentistry

Date 2024 Jun 17

PMID 38886713

Authors

Alessio Rosa

Alberto Maria Pujia

Claudio Arcuri

Affiliations

Soon will be listed here.

Abstract

Background: Post-tooth extraction, dry socket is a frequently encountered complication, causing substantial pain and hindering the healing process. Conventional approaches to manage this condition have traditionally involved the use of antiseptic dressings to diminish bacterial presence and facilitate healing. This study aims to assess the efficacy of laser therapy in the symptomatic treatment of alveolitis.

Methods: A literature search was conducted on PubMed, Embase, Scopus, Google Scholar, Web of Science, focusing on publications from 1998 to 31/01/2024 using relevant keywords. The combination of "laser" and "dry socket" was executed through the boolean connection AND.

Results: At the conclusion of the study, a total of 50 studies were identified across the three search engines, with only three selected for the current systematic study and meta-analysis. The meta-analysis indicated that laser treatment proves effective in addressing alveolitis compared to Alvogyl. However, the correlation between the two was not highly significant.

Conclusion: These findings suggest that laser therapy may serve as a viable alternative to traditional treatments for dry socket. This minimally invasive procedure has the potential to alleviate pain and promote healing with fewer associated side effects."

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References

Pal U, Singh B, Verma V . Comparative evaluation of zinc oxide eugenol versus gelatin sponge soaked in plasma rich in growth factor in the treatment of dry socket: An initial study. Contemp Clin Dent. 2013; 4(1):37-41. PMC: 3703692. DOI: 10.4103/0976-237X.111592. View

Burgoyne C, Giglio J, Reese S, Sima A, Laskin D . The efficacy of a topical anesthetic gel in the relief of pain associated with localized alveolar osteitis. J Oral Maxillofac Surg. 2009; 68(1):144-8. DOI: 10.1016/j.joms.2009.06.033. View

Haraji A, Rakhshan V, Khamverdi N, Alishahi H . Effects of intra-alveolar placement of 0.2% chlorhexidine bioadhesive gel on dry socket incidence and postsurgical pain: a double-blind split-mouth randomized controlled clinical trial. J Orofac Pain. 2013; 27(3):256-62. DOI: 10.11607/jop.1142. View

Nusair Y, Goussous Z . Quantifying the healing of dry socket using a clinical volumetric method. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006; 101(6):e89-95. DOI: 10.1016/j.tripleo.2005.11.021. View

Blum I . Contemporary views on dry socket (alveolar osteitis): a clinical appraisal of standardization, aetiopathogenesis and management: a critical review. Int J Oral Maxillofac Surg. 2002; 31(3):309-17. DOI: 10.1054/ijom.2002.0263. View

Eshghpour M, Ahrari F, Najjarkar N, Khajavi M . Comparison of the effect of low level laser therapy with alvogyl on the management of alveolar osteitis. Med Oral Patol Oral Cir Bucal. 2015; 20(3):e386-92. PMC: 4464928. DOI: 10.4317/medoral.20375. View

Sanchis J, Saez U, Penarrocha M, Gay C . Tetracycline compound placement to prevent dry socket: a postoperative study of 200 impacted mandibular third molars. J Oral Maxillofac Surg. 2004; 62(5):587-91. DOI: 10.1016/j.joms.2003.08.035. View

Torres-Lagares D, Serrera-Figallo M, Romero-Ruiz M, Infante-Cossio P, Garcia-Calderon M, Gutierrez-Perez J . Update on dry socket: a review of the literature. Med Oral Patol Oral Cir Bucal. 2005; 10(1):81-5. View

Ebell M, Siwek J, Weiss B, Woolf S, Susman J, Ewigman B . Strength of recommendation taxonomy (SORT): a patient-centered approach to grading evidence in the medical literature. J Am Board Fam Pract. 2004; 17(1):59-67. DOI: 10.3122/jabfm.17.1.59. View

10.

de Melo Junior E, Raposo M, Lisboa Neto J, Diniz M, Marcelino Junior C, Santana A . Medicinal plants in the healing of dry socket in rats: microbiological and microscopic analysis. Phytomedicine. 2002; 9(2):109-16. DOI: 10.1078/0944-7113-00087. View

11.

Simsek Kaya G, Yapici G, Savas Z, Gungormus M . Comparison of alvogyl, SaliCept patch, and low-level laser therapy in the management of alveolar osteitis. J Oral Maxillofac Surg. 2011; 69(6):1571-7. DOI: 10.1016/j.joms.2010.11.005. View

12.

Pessoa R, Oliveira S, Menezes H, de Magalhaes D . Effects of platelet-rich plasma on healing of alveolar socket: split-mouth histological and histometric evaluation in Cebus apella monkeys. Indian J Dent Res. 2010; 20(4):442-7. DOI: 10.4103/0970-9290.59448. View

13.

Bowe D, Rogers S, Stassen L . The management of dry socket/alveolar osteitis. J Ir Dent Assoc. 2012; 57(6):305-10. View

14.

Betts N, Makowski G, Shen Y, Hersh E . Evaluation of topical viscous 2% lidocaine jelly as an adjunct during the management of alveolar osteitis. J Oral Maxillofac Surg. 1995; 53(10):1140-4. DOI: 10.1016/0278-2391(95)90619-3. View

15.

ALHarthi S, Ali D, Alamry N, Alshehri M, Divakar D, BinShabaib M . Photobiomodulation for Managing "Dry Socket": A Randomised Controlled Trial. Int Dent J. 2022; 73(2):267-273. PMC: 10023530. DOI: 10.1016/j.identj.2022.06.002. View

16.

Haghighat A, Bahri Najafi R, Bazvand M, Badrian H, Khalighinejad N, Goroohi H . The Effectiveness of GECB Pastille in Reducing Complications of Dry Socket Syndrome. Int J Dent. 2012; 2012:587461. PMC: 3346972. DOI: 10.1155/2012/587461. View

17.

Bergdahl M, Hedstrom L . Metronidazole for the prevention of dry socket after removal of partially impacted mandibular third molar: a randomised controlled trial. Br J Oral Maxillofac Surg. 2004; 42(6):555-8. DOI: 10.1016/j.bjoms.2004.06.015. View

18.

Kolokythas A, Olech E, Miloro M . Alveolar osteitis: a comprehensive review of concepts and controversies. Int J Dent. 2010; 2010:249073. PMC: 2905714. DOI: 10.1155/2010/249073. View

19.

Daly B, Sharif M, Newton T, Jones K, Worthington H . Local interventions for the management of alveolar osteitis (dry socket). Cochrane Database Syst Rev. 2012; 12:CD006968. DOI: 10.1002/14651858.CD006968.pub2. View

20.

Rosa A, Pujia A, Docimo R, Arcuri C . Managing Dental Phobia in Children with the Use of Virtual Reality: A Systematic Review of the Current Literature. Children (Basel). 2023; 10(11). PMC: 10670820. DOI: 10.3390/children10111763. View