The Critical Role of the Shroom Family Proteins in Morphogenesis, Organogenesis and Disease

Overview

Journal Phenomics

Publisher Springer

Date 2024 Jun 17

PMID 38884059

Authors

Wanling Liu

Lei Xiu

Mingzhe Zhou

Tao Li

Ning Jiang

Yanmin Wan

Chao Qiu

Jian Li

Wei Hu

Wenhong Zhang

Jing Wu

Affiliations

Soon will be listed here.

Abstract

The Shroom (Shrm) family of actin-binding proteins has a unique and highly conserved Apx/Shrm Domain 2 (ASD2) motif. Shroom protein directs the subcellular localization of Rho-associated kinase (ROCK), which remodels the actomyosin cytoskeleton and changes cellular morphology via its ability to phosphorylate and activate non-muscle myosin II. Therefore, the Shrm-ROCK complex is critical for the cellular shape and the development of many tissues, including the neural tube, eye, intestines, heart, and vasculature system. Importantly, the structure and expression of Shrm proteins are also associated with neural tube defects, chronic kidney disease, metastasis of carcinoma, and X-link mental retardation. Therefore, a better understanding of Shrm-mediated signaling transduction pathways is essential for the development of new therapeutic strategies to minimize damage resulting in abnormal Shrm proteins. This paper provides a comprehensive overview of the various Shrm proteins and their roles in morphogenesis and disease.

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