Effects of TCM External Scalding Therapy on Spleen-stomach Deficiency Cold Stomachache and Inflammatory Indexes

Overview

Journal Am J Transl Res

Specialty General Medicine

Date 2024 Jun 17

PMID 38883362

Authors

Yunyi Ye

Lingling Xu

Yingyue Sheng

Affiliations

Soon will be listed here.

Abstract

Objective: To determine the efficacy and safety of traditional Chinese medicine (TCM) external scalding therapy on spleen-stomach deficiency cold stomachache.

Methods: The medical records of 98 patients with spleen-stomach deficiency cold stomachache treated in the Affiliated Hospital of Jiangnan University from January 2019 to January 2020 were collected and analyzed retrospectively. Among them, 52 patients treated with western medicine were assigned to the control group, while the other 46 patients treated additionally with TCM external scalding therapy were assigned to the observation group. The two groups were compared in terms of serum gastrin (GAS), inflammatory factors and visual analogue scale (VAS) score, adverse reaction rate and symptom remission time.

Results: After treatment, the observation group showed a significantly lower GAS level than the control group (P<0.05), along with significantly lower serum levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β) and interleukin-6 (IL-6) than the control group (all P<0.05). The observation group demonstrated significantly lower VAS score than the control group (P<0.05). The observation group experienced notably shorter remission time of dull epigastric pain, epigastric distension, fatigue and belching and acid reflux than the control group (all P<0.05), and a significantly lower incidence of adverse reactions was found in the observation group than that in the control group (P<0.05). Multivariate analysis revealed that history of alcoholism and treatment method were independent risk factors affecting patient outcomes (all P<0.05).

Conclusion: TCM external scalding therapy has shown effectiveness in treating spleen-stomach deficiency cold stomachache. It alleviates stomachache symptoms and also reduces the occurrence of adverse reactions and inflammation, holding great potential for widespread adoption in clinical practice.

References

Yu Y, Yu Y, Cheng X . Clinical effects of a traditional Chinese medicine nursing programme to intervene in gastric pain of the spleen and stomach with Qi deficiency. World J Clin Cases. 2023; 11(21):5056-5062. PMC: 10424014. DOI: 10.12998/wjcc.v11.i21.5056. View

Shin W, Kim H, Chung W . Traditional Chinese medicine for foot pain in a patient with complex regional pain syndrome: A case report. World J Clin Cases. 2023; 11(30):7424-7431. PMC: 10643069. DOI: 10.12998/wjcc.v11.i30.7424. View

Sun M, Min L, Sun Y, Fang J, Yan B . [Medication regularities of traditional Chinese medicine formulas for six kinds of pains by data-mining approach]. Zhongguo Zhong Yao Za Zhi. 2019; 44(8):1682-1688. DOI: 10.19540/j.cnki.cjcmm.20190104.001. View

Kang S, Narazaki M, Metwally H, Kishimoto T . Historical overview of the interleukin-6 family cytokine. J Exp Med. 2020; 217(5). PMC: 7201933. DOI: 10.1084/jem.20190347. View

Cao L, Chen Z, Jiang Z, Chen Q, Fan X, Xia S . Rapid rehabilitation technique with integrated traditional Chinese and Western medicine promotes postoperative gastrointestinal function recovery. World J Gastroenterol. 2020; 26(23):3271-3282. PMC: 7336322. DOI: 10.3748/wjg.v26.i23.3271. View

Lambert C, Mahevas T, Gobert D, Bravetti M, Radzik A, Poujol-Robert A . [Epigastric pain]. Rev Med Interne. 2021; 43(4):260-261. DOI: 10.1016/j.revmed.2021.07.007. View

Ding X, Wu J, Shen Q, Xu J, Mo W . Clinical control study of traditional Chinese medicine hot compress combined with traction in the treatment of cervical spondylotic radiculopathy: Study protocol. Medicine (Baltimore). 2021; 100(4):e23880. PMC: 7850636. DOI: 10.1097/MD.0000000000023880. View

Tsukioka K, Kono T, Matsumura Y, Takano T, Machida K, Iwashita T . Woman with epigastric pain. J Am Coll Emerg Physicians Open. 2021; 2(5):e12574. PMC: 8485982. DOI: 10.1002/emp2.12574. View

Jang D, Lee A, Shin H, Song H, Park J, Kang T . The Role of Tumor Necrosis Factor Alpha (TNF-α) in Autoimmune Disease and Current TNF-α Inhibitors in Therapeutics. Int J Mol Sci. 2021; 22(5). PMC: 7962638. DOI: 10.3390/ijms22052719. View

10.

Wen Y, Lu F, Zhao Y, Wang P, Yang Q, Li J . Epigastric pain syndrome: What can traditional Chinese medicine do? A randomized controlled trial of Biling Weitong Granules. World J Gastroenterol. 2020; 26(28):4170-4181. PMC: 7403800. DOI: 10.3748/wjg.v26.i28.4170. View

11.

Huang C, Lien W, Wang H . Man With Epigastric Pain. Ann Emerg Med. 2022; 79(5):e107-e108. DOI: 10.1016/j.annemergmed.2021.11.030. View

12.

Yan L, Chenni W, Fang L, LiyueYang . Medical Data Analysis of Lumbar Disc Herniation Patients after Traditional Chinese Medicine Rehabilitation Intervention Lumbar Function Recovery. Appl Bionics Biomech. 2022; 2022:1288233. PMC: 9132704. DOI: 10.1155/2022/1288233. View

13.

Therkleson T . Ginger compress therapy for adults with osteoarthritis. J Adv Nurs. 2010; 66(10):2225-33. PMC: 2984544. DOI: 10.1111/j.1365-2648.2010.05355.x. View

14.

Fang J, Du Y, Liu W, Ren J, Li Y, Chen X . Chinese consensus on chronic gastritis (2017, Shanghai). J Dig Dis. 2018; 19(4):182-203. DOI: 10.1111/1751-2980.12593. View

15.

Teschke R, Wolff A, Frenzel C, Eickhoff A, Schulze J . Herbal traditional Chinese medicine and its evidence base in gastrointestinal disorders. World J Gastroenterol. 2015; 21(15):4466-90. PMC: 4402294. DOI: 10.3748/wjg.v21.i15.4466. View

16.

Zhang K, Zhang Y, Hong S, Cao Y, Liu C . Comparative analysis of efficacy of different combination therapies of α-receptor blockers and traditional Chinese medicine external therapy in the treatment of chronic prostatitis/chronic pelvic pain syndrome: Bayesian network meta-analysis. PLoS One. 2023; 18(4):e0280821. PMC: 10118174. DOI: 10.1371/journal.pone.0280821. View

17.

Ridker P, Rane M . Interleukin-6 Signaling and Anti-Interleukin-6 Therapeutics in Cardiovascular Disease. Circ Res. 2021; 128(11):1728-1746. DOI: 10.1161/CIRCRESAHA.121.319077. View

18.

Li W, Yao C, Zhou Y, Chen S . Changes of Endothelin-1 and Calcitonin Gene-Related Peptide Concentrations in Patients with Cervical Radiculopathy after Wrist-Ankle Acupuncture-Moxibustion and Hot Compression with Chinese Herbal Medicine. Genet Res (Camb). 2022; 2021:5433742. PMC: 8710150. DOI: 10.1155/2021/5433742. View

19.

Cao L, Wang T, Lin J, Jiang Z, Chen Q, Gan H . Effect of Yikou-Sizi powder hot compress on gastrointestinal functional recovery in patients after abdominal surgery: Study protocol for a randomized controlled trial. Medicine (Baltimore). 2018; 97(38):e12438. PMC: 6160149. DOI: 10.1097/MD.0000000000012438. View

20.

Zhang H, Yang Y, Zou L . Efficacy observation of needle press needle combined with traditional Chinese medicine hot compress for postoperative nausea and vomiting intervention during anesthesia. Minerva Gastroenterol (Torino). 2023; 69(4):597-599. DOI: 10.23736/S2724-5985.23.03431-9. View