Immunohistochemical Studies on Human Brain Tumors Using Anti-Leu 7 Monoclonal Antibody in Paraffin-embedded Specimens

Overview

Journal Acta Neuropathol

Specialty Neurology

Date 1985 Jan 1

PMID 3887834

Citations 13

Authors

M Motoi

T Yoshino

K Hayashi

S Nose

Y Horie

K Ogawa

Affiliations

Soon will be listed here.

Abstract

Using the four-step peroxidase-antiperoxidase (PAP) method, the presence of the antigen recognized with anti-Leu 7 monoclonal antibody was investigated in paraffin-embedded human brain tissue and tumors. The antigen was demonstrated in the myelin sheaths, oligodendrocytes, and some choroid plexus cells in normal brain and in oligodendrogliomas, some astrocytomas and choroid plexus papillomas. The technique can be used to identify normal and neoplastic oligodendrocytes.

Citing Articles

Establishment and characterization of a human malignant choroids plexus papilloma cell line (HIBCPP).

Ishiwata I, Ishiwata C, Ishiwata E, Sato Y, Kiguchi K, Tachibana T Hum Cell. 2005; 18(1):67-72.

PMID: 16130902 DOI: 10.1111/j.1749-0774.2005.tb00059.x.

Widespread cytoskeletal pathology characterizes corticobasal degeneration.

Feany M, Dickson D Am J Pathol. 1995; 146(6):1388-96.

PMID: 7778678 PMC: 1870913.

Cross reactivity of anti-epithelial membrane antigen monoclonal for reactive and neoplastic glial cells.

Hitchcock E, MORRIS C J Neurooncol. 1987; 4(4):345-52.

PMID: 3553440 DOI: 10.1007/BF00195605.

Immunohistochemical recognition of human neuroepithelial tumors by anti-Leu 7 (HNK-1) monoclonal antibody.

Perentes E, Rubinstein L Acta Neuropathol. 1986; 69(3-4):227-33.

PMID: 3515832 DOI: 10.1007/BF00688298.

Differential expression of glial- and neuronal-associated antigens in human tumors of the central and peripheral nervous system.

Reifenberger G, Szymas J, WECHSLER W Acta Neuropathol. 1987; 74(2):105-23.

PMID: 3314309 DOI: 10.1007/BF00692841.

References

Mori S, Mohri N, Morita H, Yamaguchi K, SHIMAMINE T . The distribution of cells expressing a natural killer cell marker (HNK-1) in normal human lymphoid organs and malignant lymphomas. Virchows Arch B Cell Pathol Incl Mol Pathol. 1983; 43(3):253-63. DOI: 10.1007/BF02932960. View

Schuller-Petrovic S, Gebhart W, Lassmann H, Rumpold H, Kraft D . A shared antigenic determinant between natural killer cells and nervous tissue. Nature. 1983; 306(5939):179-81. DOI: 10.1038/306179a0. View

Si L, Whiteside T . Tissue distribution of human NK cells studied with anti-Leu-7 monoclonal antibody. J Immunol. 1983; 130(5):2149-55. View

Abo T, Balch C . A differentiation antigen of human NK and K cells identified by a monoclonal antibody (HNK-1). J Immunol. 1981; 127(3):1024-9. View