Benefits of Uric Acid-lowering Medication After Bariatric Surgery in Patients with Gout

Overview

Journal BMC Surg

Publisher Biomed Central

Specialty General Surgery

Date 2024 Jun 14

PMID 38877436

Authors

Ke Song

Ming He

Xiangxin Kong

Yin Xian

Yuan Zhang

Xing Xie

Sijun Xie

Aimei Jia

Yixing Ren

Affiliations

Soon will be listed here.

Abstract

Background/purpose: Patients with gout are at risk for increased serum uric acid (SUA) levels and gout attacks in the short term after undergoing bariatric surgery, and the purpose of this study was to evaluate the benefits of short-term treatment with uric acid-lowering medication after bariatric surgery for the control of gout attacks and SUA levels in patients with gout.

Methods: 71 patients who underwent SG from January 2020 to December 2022 were prospectively included. These patients were diagnosed with hyperuricemia before surgery and had a history of gout attacks. Patients were classified into a drug-treatment group (DTG, n = 32) and a non-drug-treatment group (NDTG, n = 39) according to whether they took uric acid-lowering medication after surgery. Changes in the number of gout attacks, body mass index (BMI), and SUA levels at 1 week, 1 month, 3 months, and 6 months after bariatric surgery were measured in both groups.

Results: In the DTG, 22 patients (68.8%) experienced an increase in SUA within 1 week, 3 patients (9.4%) had an acute attack of gout within the first month, and no patients had a gout attack thereafter. In the NDTG, 35 patients (89.7%) experienced an increase in SUA within 1 week, 7 patients (17.9%) had an acute gout attack within the first month, and 4 patients (10.3%) experienced gout attacks between month 1 and month 3 postoperatively. Both groups were free of gout attacks between the 3rd and 6th postoperative month and showed a significant decrease in SUA and BMI by the sixth month.

Conclusion: In patients with gout, continued use of uric acid-lowering medication after bariatric surgery is beneficial in reducing the number of gout attacks and the risk of rising SUA.

Citing Articles

Sleeve gastrectomy ameliorates renal injury in obesity-combined hyperuricemic nephropathy mice by modulating the AMPK/Nrf2/ABCG2 pathway.

Song K, Kong X, Zhang Z, Xian Y, He M, Zhang Y Sci Rep. 2024; 14(1):22834.

PMID: 39354116 PMC: 11445534. DOI: 10.1038/s41598-024-73807-9.

Research progress on bariatric surgery for hyperuricemia.

Song K, Kong X, Yu Z, Xiao H, Ren Y BMC Surg. 2024; 24(1):235.

PMID: 39169366 PMC: 11337558. DOI: 10.1186/s12893-024-02525-w.

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