HPV-18 E6 Enhances the Interaction Between EMILIN2 and SNX27 to Promote WNT Signaling

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 2024 Jun 14

PMID 38874360

Authors

Justyna Broniarczyk

Oscar Trejo-Cerro

Paola Massimi

Nezka Kavcic

Michael P Myers

Lawrence Banks

Affiliations

Soon will be listed here.

Abstract

Importance: This study demonstrates that HPV E6 blocks EMILIN2 inhibition of WNT1 signaling, thereby enhancing cell proliferation in HPV-positive tumor cells. This involves a novel mechanism whereby the E6 PBM actually contributes toward enhancing the interaction between SNX27 and EMILIN2, suggesting that the mode of recognition of SNX27 by E6 and EMILIN2 is different. This is the first example of the E6 PBM altering a PDZ domain-containing protein to enhance potential substrate recognition.

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