Enzyme Immunoassay of Serum Beta-2-microglobulin Levels in Various Histological Forms of Leprosy with Special Reference to Its Elevation in Type I and Type II Lepra Reactions

Overview

Journal J Clin Microbiol

Specialty Microbiology

Date 1985 Apr 1

PMID 3886698

Authors

K Saha

A Bhatnagar

V K Sharma

A K Chakrabarty

Affiliations

Soon will be listed here.

Abstract

The mean beta-2-microglobulin level in serum (3,362 +/- 2,494 micrograms/liter) for 76 leprosy patients, including 9 borderline-tuberculoid, 8 borderline-borderline, 9 borderline-lepromatous, and 16 lepromatous-lepromatous patients and 34 patients with type I or type II lepra reactions, was significantly higher (P less than 0.001) than that (2,122 +/- 1,844 micrograms/liter) for 35 normal subjects. It decreased significantly (P less than 0.001) as the disease glided down from borderline tuberculoid (3,173 +/- 899 micrograms/liter) to the lepromatous end (1,813 +/- 1,391 micrograms/liter). At the onset of type I or type II reaction, the mean beta-2-microglobulin level in serum increased (4,447 +/- 2,863 micrograms/liter), and it remained unchanged (4,433 +/- 2,623 micrograms/liter) after clinical remission. The beta-2-microglobulin level in serum decreased in 55.5% of the patients tested after subsidence of reaction. The level was significantly higher in patients with type II reactions (5,433 +/- 3,299 micrograms/liter) than in patients with type I reactions (3,558 +/- 2,171 micrograms/liter).

References

RIDLEY D, Jopling W . Classification of leprosy according to immunity. A five-group system. Int J Lepr Other Mycobact Dis. 1966; 34(3):255-73. View

Thomas G, Karat A, Rao P, Prathapkumar C . Changes in renal function during reactive phases of lepromatous leprosy. Int J Lepr Other Mycobact Dis. 1970; 38(2):170-6. View

Evrin P, Wibell L . Serum 2 -microglobulin in various disorders. Clin Chim Acta. 1973; 43(2):183-6. DOI: 10.1016/0009-8981(73)90449-x. View

Saha K, Dutta R, Mittal M . Immunologic aspects of leprosy as related to leucocytic isoantibodies and platelet aggregating factors. Int J Lepr Other Mycobact Dis. 1975; 43(3):239-48. View

Gupta S, Bajaj A, Govil D, Sinha S, Kumar R . A study of percutaneous renal biopsy in lepromatous leprosy. Lepr India. 1981; 53(2):179-84. View

Bajaj A, Gupta S, Sinha S, Govil D, Gaur U . Sequential renal functions in leprosy. Lepr India. 1981; 53(2):185-9. View

Schweizer R, MOORE R, BARTUS S, Bow L, Hayden J . Beta 2-microglobulin monitoring after renal transplantation. Transplant Proc. 1981; 13(3):1620-3. View

Bullock W, Watson S, Nelson K, Schauf V, Makonkawkeyoon S, Jacobson R . Aberrant immunoregulatory control of B lymphocyte function in lepromatous leprosy. Clin Exp Immunol. 1982; 49(1):105-14. PMC: 1536644. View

Saha K, Chakraborty A, Sharma V, Sehgal V . An appraisal of third complement component (C3) and breakdown product (C3d) in erythema nodosum leprosum (ENL). Lepr Rev. 1982; 53(4):253-60. DOI: 10.5935/0305-7518.19820031. View

10.

Maire M, Barnet M, Carpentier N, MIESCHER P, Lambert P . Identification of components of IC purified from human sera. I. Immune complexes purified from sera of patients with SLE. Clin Exp Immunol. 1983; 51(2):215-24. PMC: 1536884. View

11.

Chakrabarty A, Maire M, Saha K, Lambert P . Identification of components of IC purified from human sera. II. Demonstration of mycobacterial antigens in immune complexes isolated from sera of lepromatous patients. Clin Exp Immunol. 1983; 51(2):225-31. PMC: 1536874. View

12.

Barnstable C, Jones E, Crumpton M . Isolation, structure and genetics of HLA-A, -B, -C and -DRw (Ia) antigens. Br Med Bull. 1978; 34(3):241-6. DOI: 10.1093/oxfordjournals.bmb.a071504. View

13.

Child J, Spati B, Illingworth S, Barnard D, Corbett S, Simmons A . Serum beta 2 microglobulin and C-reactive protein in the monitoring of lymphomas: findings in a multicenter study and experience in selected patients. Cancer. 1980; 45(2):318-26. DOI: 10.1002/1097-0142(19800115)45:2<318::aid-cncr2820450220>3.0.co;2-c. View

14.

Jacobsen F, Christensen C, Mogensen C, HEILSKOV N . Evaluation of kidney function after meals. Lancet. 1980; 1(8163):319. DOI: 10.1016/s0140-6736(80)90821-1. View

15.

BERNIER G . beta 2-Microglobulin: structure, function and significance. Vox Sang. 1980; 38(6):323-7. DOI: 10.1111/j.1423-0410.1980.tb04500.x. View

16.

Poulik M, Perry D, Sekine T . Statistical analysis of beta 2-microglobulin levels in sera of lung and GI tract cancer patients. Vox Sang. 1980; 38(6):328-33. DOI: 10.1111/j.1423-0410.1980.tb04501.x. View

17.

Revillard J . Significance of beta 2-microglobulin in liver diseases. Vox Sang. 1980; 38(6):339-42. DOI: 10.1111/j.1423-0410.1980.tb04503.x. View

18.

Hall 3rd P, Ricanati E, Vacca C . Renal metabolism of beta 2-microglobulin. Experimental animal studies. Vox Sang. 1980; 38(6):343-7. DOI: 10.1111/j.1423-0410.1980.tb04504.x. View

19.

Lambert P, Berney M, Kazyumba G . Immune complexes in serum and in cerebrospinal fluid in African trypanosomiasis. Correlation with polyclonal B cell activation and with intracerebral immunoglobulin synthesis. J Clin Invest. 1981; 67(1):77-85. PMC: 371574. DOI: 10.1172/JCI110035. View

20.

Bahr G, Rook G, Moreno E, Lydyard P, Modabber F, Stanford J . Use of the ELISA to screen for anti-thymocyte and anti-beta 2-microglobulin antibodies in leprosy and SLE. Immunology. 1980; 41(4):865-73. PMC: 1458311. View