Progress of the Study of Pericytes and Their Potential Research Value in Adenomyosis

Overview

Journal Sci Prog

Publisher Sage Publications

Specialty Science

Date 2024 Jun 12

PMID 38863331

Authors

Chenyu Zhang

Jinghua Shi

Yi Dai

Xiaoyan Li

Jinhua Leng

Affiliations

Soon will be listed here.

Abstract

Pericytes (PCs) are versatile cells integral to the microcirculation wall, exhibiting specific stem cell traits. They are essential in modulating blood flow, ensuring vascular permeability, maintaining homeostasis, and aiding tissue repair process. Given their involvement in numerous disease-related pathological and physiological processes, the regulation of PCs has emerged as a focal point of research. Adenomyosis is characterized by the presence of active endometrial glands and stroma encased by an enlarged and proliferative myometrial layer, further accompanied by fibrosis and new blood vessel formation. This distinct pathological condition might be intricately linked with PCs. This article comprehensively reviews the markers associated with PCs, their contributions to angiogenesis, blood flow modulation, and fibrotic processes. Moreover, it provides a comprehensive overview of the current research on adenomyosis pathophysiology, emphasizing the potential correlation and future implications regarding PCs and the development of adenomyosis.

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