Dysregulation of Exosomal MiRNAs and Their Related Genes in Head and Neck Cancer Patients

Overview

Journal Future Oncol

Specialty Oncology

Date 2024 Jun 11

PMID 38861304

Authors

Muhammad Rizwan

Ishrat Mahjabeen

Nida Sarosh Ashraf

Maryam Arshad

Muhammad Shahbaz Haris

Mahmood Akhtar Kayani

Affiliations

Soon will be listed here.

Abstract

The present study aimed to figure out the potential role of exosomal microRNAs, and their targeted genes in HNC detection/diagnosis. In the present study, exosomes were extracted from the serum samples of 400 HNC patients and 400 healthy controls. Exosomes were characterized using TEM, NTA, TEM-immunogold labeling and ELISA. Quantitative PCR was used to measure the expression level of exosomal miRNA-19a, miRNA-19b and targeted genes and in HNC patients and controls. The deregulation of miR-19a (p < 0.01), miR-19b (p < 0.03), (p < 0.04) and (p < 0.04) was observed in HNC patients vs controls. ROC curve and Kaplan-Meier analysis showed the good diagnostic/prognostic value of selected exosomal microRNAs and related genes in HNC patients.

Citing Articles

Deregulation of Exosomal miR-17, miR-20a and TGFBR2 in Head and Neck Cancer Patients.

Rizwan M, Mahjabeen I, Haris M, Qayyum F, Kayani M Technol Cancer Res Treat. 2025; 24:15330338251323314.

PMID: 39989256 PMC: 11848883. DOI: 10.1177/15330338251323314.

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