Community Readiness and Acceptance for the Implementation of a Novel Malaria Vaccine Among At-risk Children in Sub-saharan Africa: a Systematic Review Protocol

Overview

Journal Malar J

Publisher Biomed Central

Specialty Tropical Medicine

Date 2024 Jun 10

PMID 38858779

Authors

Eustes Kigongo

Amir Kabunga

Marc Sam Opollo

Raymond Tumwesigye

Marvin Musinguzi

Anne Ruth Akello

Jannat Nabaziwa

Temesgen Geta Hardido

Sean Steven Puleh

Affiliations

Soon will be listed here.

Abstract

Background: The World Health Organization novel malaria vaccine for at-risk children has the potential to greatly reduce the current malaria burden in sub-Saharan Africa. However, most studies have reported contradictory findings regarding community willingness for the vaccine, which could easily undermine the expected benefits of the vaccine. This study aims to ascertain the current state of community readiness and acceptance for the implementation of a novel malaria vaccine (RTS,S/ASO1) among at-risk children in sub-Saharan Africa, based on available evidence.

Methods: This study will follow the Preferred Reporting Items for Systematic Reviews and Meta-analyses protocol (PRISMA-P) guidelines. Relevant studies will be comprehensively searched from PubMed, ScienceDirect, Web of Science, Google Scholar, and African journals online, in accordance with the Cochrane search guidelines. Two independent reviewers will screen titles, abstracts and full texts of eligible studies based on some specified eligibility criteria. When it is feasible to conduct a meta-analysis, a random effects model will be employed to estimate the common effect due to anticipated high heterogeneity of the data. The effect measure for readiness or acceptance will be reported as a pooled proportion with corresponding 95% confidence interval. Additionally, odds ratios with 95% confidence interval will be estimated to assess factors associated with readiness. These will be presented on a forest plot.

Dissemination Plans: The findings of the study will be peer-reviewed and published in a scientific journal. Conference presentations will also be made to the different stakeholders in the malaria vaccination campaigns.

Systematic Review Registration: The protocol has been registered with PROSPERO Registration Number: CRD42023480528.

References

Bingham A, Gaspar F, Lancaster K, Conjera J, Collymore Y, Ba-Nguz A . Community perceptions of malaria and vaccines in two districts of Mozambique. Malar J. 2012; 11:394. PMC: 3519522. DOI: 10.1186/1475-2875-11-394. View

Abdulkadir B, Ajayi I . Willingness to accept malaria vaccine among caregivers of under-5 children in Ibadan North Local Government Area, Nigeria. Malariaworld J. 2024; 6:2. PMC: 11107874. DOI: 10.5281/zenodo.10870005. View

Page M, McKenzie J, Bossuyt P, Boutron I, Hoffmann T, Mulrow C . The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021; 372:n71. PMC: 8005924. DOI: 10.1136/bmj.n71. View

Sarfo J, Amoadu M, Kordorwu P, Adams A, Gyan T, Osman A . Malaria amongst children under five in sub-Saharan Africa: a scoping review of prevalence, risk factors and preventive interventions. Eur J Med Res. 2023; 28(1):80. PMC: 9936673. DOI: 10.1186/s40001-023-01046-1. View

Ma L, Wang Y, Yang Z, Huang D, Weng H, Zeng X . Methodological quality (risk of bias) assessment tools for primary and secondary medical studies: what are they and which is better?. Mil Med Res. 2020; 7(1):7. PMC: 7049186. DOI: 10.1186/s40779-020-00238-8. View

Adeloye D, Jacobs W, Amuta A, Ogundipe O, Mosaku O, Gadanya M . Coverage and determinants of childhood immunization in Nigeria: A systematic review and meta-analysis. Vaccine. 2017; 35(22):2871-2881. DOI: 10.1016/j.vaccine.2017.04.034. View

Oladipo H, Tajudeen Y, Oladunjoye I, Yusuff S, Yusuf R, Oluwaseyi E . Increasing challenges of malaria control in sub-Saharan Africa: Priorities for public health research and policymakers. Ann Med Surg (Lond). 2022; 81:104366. PMC: 9421173. DOI: 10.1016/j.amsu.2022.104366. View

Sulaiman S, Musa M, Tsiga-Ahmed F, Dayyab F, Sulaiman A, Bako A . A systematic review and meta-analysis of the prevalence of caregiver acceptance of malaria vaccine for under-five children in low-income and middle-income countries (LMICs). PLoS One. 2022; 17(12):e0278224. PMC: 9715017. DOI: 10.1371/journal.pone.0278224. View

Ouzzani M, Hammady H, Fedorowicz Z, Elmagarmid A . Rayyan-a web and mobile app for systematic reviews. Syst Rev. 2016; 5(1):210. PMC: 5139140. DOI: 10.1186/s13643-016-0384-4. View

10.

Bown M, Sutton A . Quality control in systematic reviews and meta-analyses. Eur J Vasc Endovasc Surg. 2010; 40(5):669-77. DOI: 10.1016/j.ejvs.2010.07.011. View

11.

Sterne J, Sutton A, Ioannidis J, Terrin N, Jones D, Lau J . Recommendations for examining and interpreting funnel plot asymmetry in meta-analyses of randomised controlled trials. BMJ. 2011; 343:d4002. DOI: 10.1136/bmj.d4002. View

12.

Asmare G . Willingness to accept malaria vaccine among caregivers of under-5 children in Southwest Ethiopia: a community based cross-sectional study. Malar J. 2022; 21(1):146. PMC: 9097094. DOI: 10.1186/s12936-022-04164-z. View

13.

Morgan R, Whaley P, Thayer K, Schunemann H . Identifying the PECO: A framework for formulating good questions to explore the association of environmental and other exposures with health outcomes. Environ Int. 2018; 121(Pt 1):1027-1031. PMC: 6908441. DOI: 10.1016/j.envint.2018.07.015. View

14.

Higgins J, Thompson S, Spiegelhalter D . A re-evaluation of random-effects meta-analysis. J R Stat Soc Ser A Stat Soc. 2009; 172(1):137-159. PMC: 2667312. DOI: 10.1111/j.1467-985X.2008.00552.x. View

15.

Dutta T, Meyerson B, Agley J, Barnes P, Sherwood-Laughlin C, Nicholson-Crotty J . A qualitative analysis of vaccine decision makers' conceptualization and fostering of 'community engagement' in India. Int J Equity Health. 2020; 19(1):185. PMC: 7574459. DOI: 10.1186/s12939-020-01290-5. View

16.

Tabiri D, Ouedraogo J, Nortey P . Factors associated with malaria vaccine uptake in Sunyani Municipality, Ghana. Malar J. 2021; 20(1):325. PMC: 8314499. DOI: 10.1186/s12936-021-03857-1. View