Fingerprint Sign of the Henle Fibre Layer in Epiretinal Membrane: a Cross-sectional and Longitudinal Study

Overview

Journal Graefes Arch Clin Exp Ophthalmol

Specialty Ophthalmology

Date 2024 Jun 10

PMID 38856954

Authors

Young Ho Kim

Ariunaa Togloom

Jaeryung Oh

Affiliations

Soon will be listed here.

Abstract

Purpose: To investigate the incidence and distribution of fingerprint-like microwaves in the Henle fibre layer (HFL) of the eyes with epiretinal membrane (ERM).

Methods: Patients with idiopathic ERM were included. The fingerprint sign was defined using en-face optical coherence tomography images of the HFL, and its extent was classified into three grades.

Results: At baseline, fingerprint sign was found in 70 of 83 (84.3%) eyes with ERM and was more frequently observed in eyes with a higher ERM stage (P < 0.001). Its extent increased (P < 0.001) with an increase in ERM stage or the central macular thickness (P < 0.001). Best corrected visual acuity (BCVA) was worse in eyes with a fingerprint sign than in those without (P = 0.024). Metamorphopsia was more common in eyes with a greater extent of fingerprint-like microwaves (P = 0.048). The fingerprint sign persisted over a mean follow-up period of 18.0 ± 23.3 without surgery. In 45 eyes that underwent surgery, the extent of fingerprint-like microwaves decreased at 1.2 months (P = 0.001), and further decreased at 13.7 months postoperatively (P = 0.019). However, the proportion of eyes with a fingerprint sign after surgery was similar to that observed preoperatively (P = 0.912).

Conclusions: Fingerprint-like microwaves were commonly found in eyes with ERM and were associated with ERM severity and BCVA. The microwaves remained long after surgery, although their extent may have decreased after the ERM was resolved. These results suggest that ERM traction may cause long-lasting changes in the HFL.

References

Fraser-Bell S, Guzowski M, Rochtchina E, Wang J, Mitchell P . Five-year cumulative incidence and progression of epiretinal membranes: the Blue Mountains Eye Study. Ophthalmology. 2003; 110(1):34-40. DOI: 10.1016/s0161-6420(02)01443-4. View

Bu S, Kuijer R, Li X, Hooymans J, Los L . Idiopathic epiretinal membrane. Retina. 2014; 34(12):2317-35. DOI: 10.1097/IAE.0000000000000349. View

WILKINS J, Puliafito C, Hee M, Duker J, Reichel E, Coker J . Characterization of epiretinal membranes using optical coherence tomography. Ophthalmology. 1996; 103(12):2142-51. DOI: 10.1016/s0161-6420(96)30377-1. View

Kinoshita T, Imaizumi H, Okushiba U, Miyamoto H, Ogino T, Mitamura Y . Time course of changes in metamorphopsia, visual acuity, and OCT parameters after successful epiretinal membrane surgery. Invest Ophthalmol Vis Sci. 2012; 53(7):3592-7. DOI: 10.1167/iovs.12-9493. View

Suh M, Seo J, Park K, Yu H . Associations between macular findings by optical coherence tomography and visual outcomes after epiretinal membrane removal. Am J Ophthalmol. 2008; 147(3):473-480.e3. DOI: 10.1016/j.ajo.2008.09.020. View

Inoue M, Morita S, Watanabe Y, Kaneko T, Yamane S, Kobayashi S . Inner segment/outer segment junction assessed by spectral-domain optical coherence tomography in patients with idiopathic epiretinal membrane. Am J Ophthalmol. 2010; 150(6):834-9. DOI: 10.1016/j.ajo.2010.06.006. View

Arichika S, Hangai M, Yoshimura N . Correlation between thickening of the inner and outer retina and visual acuity in patients with epiretinal membrane. Retina. 2009; 30(3):503-8. DOI: 10.1097/IAE.0b013e3181bd2d65. View

Oster S, Mojana F, Brar M, Yuson R, Cheng L, Freeman W . Disruption of the photoreceptor inner segment/outer segment layer on spectral domain-optical coherence tomography is a predictor of poor visual acuity in patients with epiretinal membranes. Retina. 2009; 30(5):713-8. DOI: 10.1097/IAE.0b013e3181c596e3. View

Bae K, Choi J, Kim K, Kang S . EN-FACE OPTICAL COHERENCE TOMOGRAPHY IN PATIENTS WITH EPIRETINAL MEMBRANE: Intuitive Method for Predicting Functional Outcomes. Retina. 2019; 40(10):1972-1979. DOI: 10.1097/IAE.0000000000002686. View

10.

Hirano M, Morizane Y, Kanzaki Y, Kimura S, Hosokawa M, Shiode Y . EN FACE IMAGE-BASED ANALYSIS OF RETINAL TRACTION CAUSED BY EPIRETINAL MEMBRANE AND ITS RELATIONSHIP WITH VISUAL FUNCTIONS. Retina. 2019; 40(7):1262-1271. DOI: 10.1097/IAE.0000000000002569. View

11.

Rispoli M, Le Rouic J, Lesnoni G, Colecchio L, Catalano S, Lumbroso B . Retinal surface en face optical coherence tomography: a new imaging approach in epiretinal membrane surgery. Retina. 2012; 32(10):2070-6. DOI: 10.1097/IAE.0b013e3182562076. View

12.

Govetto A, Bhavsar K, Virgili G, Gerber M, Freund K, Curcio C . Tractional Abnormalities of the Central Foveal Bouquet in Epiretinal Membranes: Clinical Spectrum and Pathophysiological Perspectives. Am J Ophthalmol. 2017; 184:167-180. DOI: 10.1016/j.ajo.2017.10.011. View

13.

Li K, Young B, Miller J, Besirli C . Concentric Macular Rings Without Ocular Pathology. Ophthalmic Surg Lasers Imaging Retina. 2021; 52(6):353-355. DOI: 10.3928/23258160-20210528-09. View

14.

Ramtohul P, Comet A, Denis D . Multimodal Imaging Correlation of the Concentric Macular Rings Sign in Foveal Hypoplasia: A Distinctive Henle Fiber Layer Geometry. Ophthalmol Retina. 2020; 4(9):946-953. DOI: 10.1016/j.oret.2020.03.022. View

15.

Spiteri Cornish K, Reddy A, McBain V . Concentric macular rings sign in patients with foveal hypoplasia. JAMA Ophthalmol. 2014; 132(9):1084-8. DOI: 10.1001/jamaophthalmol.2014.1715. View

16.

Missaka R, Goldbaum M, Machado C, Cunningham Jr E, Souto F, Lavezzo M . Fingerprint sign in Vogt-Koyanagi-Harada disease: a case series. Int J Retina Vitreous. 2022; 8(1):7. PMC: 8751277. DOI: 10.1186/s40942-021-00356-y. View

17.

Jadon T, Sadda S, Singh G, Narayan P, Chhablani J, Venkatesh P . NOVEL RETINAL IMAGING ABNORMALITIES IN ALPORT SYNDROME. Retin Cases Brief Rep. 2023; 17(5):499-503. DOI: 10.1097/ICB.0000000000001265. View

18.

Griffin S, McDonald H, Johnson R, Jumper J, Fu A, Cunningham Jr E . FINGERPRINT SIGN OF THE HENLE FIBER LAYER. Retina. 2020; 41(2):381-386. PMC: 7959252. DOI: 10.1097/IAE.0000000000002875. View

19.

Bringmann A, Barth T, Ziemssen F . Morphology of foveal hypoplasia: Hyporeflective zones in the Henle fiber layer of eyes with high-grade foveal hypoplasia. PLoS One. 2022; 17(4):e0266968. PMC: 9007365. DOI: 10.1371/journal.pone.0266968. View

20.

Park S, Choi S, Zawadzki R, Werner J . Fine retinal striae associated with epiretinal membrane visualized using adaptive optics. Retin Cases Brief Rep. 2012; 3(3):233-6. PMC: 3413271. DOI: 10.1097/ICB.0b013e31816b31bb. View