Novel Protective Circulating MiRNA Are Associated with Preserved Vitamin D Levels in Patients with Mild COVID-19 Presentation at Hospital Admission Not Progressing into Severe Disease

Overview

Journal Endocrine

Specialty Endocrinology

Date 2024 Jun 10

PMID 38856841

Authors

Luigi Di Filippo

Umberto Terenzi

Giovanni Di Ienno

Silvia Trasciatti

Silvano Bonaretti

Andrea Giustina

Affiliations

Soon will be listed here.

Abstract

Purpose: Low vitamin D levels were reported to negatively influence the outcomes of acute COVID-19, as well as other biochemical markers were linked to COVID-19, including microRNAs (miRNAs). This study aimed to prospectively evaluate miRNAs and vitamin D relationship in predicting COVID-19 outcomes.

Methods: COVID-19 patients were part of a previously reported cohort and enrolled in a matched-ratio based on the presence/or not of severe disease at hospital admission. 25(OH) vitamin D levels and miRNAs expression were evaluated.

Results: Patients affected by non-severe COVID-19 were characterized by a higher expression of miRNAs hsa-miR-3115 and hsa-miR-7151-3p, as compared to those affected by severe disease. In non-severe patients, these miRNAs were more frequently expressed in those who subsequently did not develop worsening outcomes. In addition, patients with miRNA-7151 expression and without worsening disease were characterized by higher 25(OH) vitamin D levels and lower prevalence of vitamin D deficiency.

Conclusions: The expression of two novel miRNAs was reported for the first-time to be associated with a less severe COVID-19 form and to prospectively predict the occurrence of disease outcome. Furthermore, the association observed between vitamin D deficiency and lack of miRNA-7151 expression in COVID-19 patients with worse outcomes may support the hypothesis that the co-existence of these two conditions may have a strong negative prognostic role.

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