Reuniens Thalamus Recruits Recurrent Excitation in Medial Prefrontal Cortex

Overview

Journal bioRxiv

Date 2024 Jun 10

PMID 38854099

Authors

Gil Vantomme

Gabrielle Devienne

Jacob M Hull

John R Huguenard

Affiliations

Soon will be listed here.

Abstract

Significance Statement: The interactions between medial prefrontal cortex and hippocampus are crucial for memory formation and retrieval. Yet, it is still poorly understood how the functional connectivity of direct and indirect pathways underlies these functions. This research explores the synaptic connectivity of the indirect pathway through the Reuniens nucleus of the thalamus using electrophysiological recordings and optogenetic manipulations. The study found that Reuniens stimulation recruits recurrent and long-lasting activity in mPFC - a phenomenon not previously recorded. This recurrent activity might create a temporal window ideal for coincidence detection and be an underlying mechanism for memory formation and retrieval.

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