Relationship Between Change in Physical Activity and Risk of Metabolic Syndrome: A Prospective Cohort Study

Overview

Journal J Obes Metab Syndr

Date 2024 Jun 9

PMID 38852947

Authors

Doo Yong Park

On Lee

Yong Ho Lee

Chung Gun Lee

Yeon Soo Kim

Affiliations

Soon will be listed here.

Abstract

Background: This study investigates the relationship between changes in physical activity levels and risk of metabolic syndrome.

Methods: This study examined 1,686 adults aged 40 to 69 years from a community-based cohort study with complete 1st to 4th follow-up data between 2011 and 2020. Changes in physical activity were evaluated through baseline and follow-up surveys using physical activity questionnaires. Metabolic syndrome was diagnosed according to the International Diabetes Federation criteria. A survival analysis was conducted using a multivariate extended Cox regression model with a significance level set at <0.05.

Results: Participants were divided into groups according to physical activity levels. The newly inactive group (vigorous physical activity ≤150 minutes at first follow-up) had a 36% increase in the hazard ratio (HR) for metabolic syndrome compared with the consistently inactive group (≤150 minutes at both baseline and first follow-up) (HR, 1.36; 95% confidence interval [CI], 1.04 to 1.79). The newly active group (walking ≤420 minutes per week at baseline and >420 minutes per week at first follow-up) had a 25% decrease in the HR for metabolic syndrome compared with the consistently inactive group (walking ≤420 minutes per week at both baseline and first follow-up) (HR, 0.75; 95% CI, 0.57 to 0.98).

Conclusion: Changes in physical activity levels are associated with risk of metabolic syndrome. These results provide important insights for future investigations into the link between physical activity changes and disease occurrence.

References

Nam J, Kim J, Cho K, Choi Y, Choi J, Shin J . Associations of sitting time and occupation with metabolic syndrome in South Korean adults: a cross-sectional study. BMC Public Health. 2016; 16:943. PMC: 5015318. DOI: 10.1186/s12889-016-3617-5. View

Moreau K, Degarmo R, Langley J, McMahon C, Howley E, Bassett Jr D . Increasing daily walking lowers blood pressure in postmenopausal women. Med Sci Sports Exerc. 2001; 33(11):1825-31. DOI: 10.1097/00005768-200111000-00005. View

Krause N, Brand R, Arah O, Kauhanen J . Occupational physical activity and 20-year incidence of acute myocardial infarction: results from the Kuopio Ischemic Heart Disease Risk Factor Study. Scand J Work Environ Health. 2015; 41(2):124-39. DOI: 10.5271/sjweh.3476. View

Boyle L, Credeur D, Jenkins N, Padilla J, Leidy H, Thyfault J . Impact of reduced daily physical activity on conduit artery flow-mediated dilation and circulating endothelial microparticles. J Appl Physiol (1985). 2013; 115(10):1519-25. PMC: 3841822. DOI: 10.1152/japplphysiol.00837.2013. View

Alberti K, Eckel R, Grundy S, Zimmet P, Cleeman J, Donato K . Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation;.... Circulation. 2009; 120(16):1640-5. DOI: 10.1161/CIRCULATIONAHA.109.192644. View

Johnson B, Mather K, Wallace J . Mechanotransduction of shear in the endothelium: basic studies and clinical implications. Vasc Med. 2011; 16(5):365-77. DOI: 10.1177/1358863X11422109. View

Baik S, Fung K, McDonald C . The Mortality Risk of Proton Pump Inhibitors in 1.9 Million US Seniors: An Extended Cox Survival Analysis. Clin Gastroenterol Hepatol. 2021; 20(4):e671-e681. DOI: 10.1016/j.cgh.2021.01.014. View

Zajac-Gawlak I, Pelclova J, Groffik D, Pridalova M, Nawrat-Szoltysik A, Kroemeke A . Does physical activity lower the risk for metabolic syndrome: a longitudinal study of physically active older women. BMC Geriatr. 2021; 21(1):11. PMC: 7789662. DOI: 10.1186/s12877-020-01952-7. View

Amirfaiz S, Shahril M . Objectively Measured Physical Activity, Sedentary Behavior, and Metabolic Syndrome in Adults: Systematic Review of Observational Evidence. Metab Syndr Relat Disord. 2018; 17(1):1-21. DOI: 10.1089/met.2018.0032. View

10.

Janssen I, Ross R . Vigorous intensity physical activity is related to the metabolic syndrome independent of the physical activity dose. Int J Epidemiol. 2012; 41(4):1132-40. PMC: 3429871. DOI: 10.1093/ije/dys038. View

11.

Ko K, Kim E, Baek U, Gang Z, Kang S . The relationship between physical activity levels and metabolic syndrome in male white-collar workers. J Phys Ther Sci. 2016; 28(11):3041-3046. PMC: 5140796. DOI: 10.1589/jpts.28.3041. View

12.

Fahed G, Aoun L, Zerdan M, Allam S, Zerdan M, Bouferraa Y . Metabolic Syndrome: Updates on Pathophysiology and Management in 2021. Int J Mol Sci. 2022; 23(2). PMC: 8775991. DOI: 10.3390/ijms23020786. View

13.

Isomaa B, Almgren P, Tuomi T, Forsen B, Lahti K, Nissen M . Cardiovascular morbidity and mortality associated with the metabolic syndrome. Diabetes Care. 2001; 24(4):683-9. DOI: 10.2337/diacare.24.4.683. View

14.

ONeill S, ODriscoll L . Metabolic syndrome: a closer look at the growing epidemic and its associated pathologies. Obes Rev. 2014; 16(1):1-12. DOI: 10.1111/obr.12229. View

15.

Macias N, Espinosa-Montero J, Monterrubio-Flores E, Hernandez-Barrera L, Medina-Garcia C, Gallegos-Carrillo K . Screen-Based Sedentary Behaviors and Their Association With Metabolic Syndrome Components Among Adults in Mexico. Prev Chronic Dis. 2021; 18:E95. PMC: 8588869. DOI: 10.5888/pcd18.210041. View

16.

Trapp E, Chisholm D, Freund J, Boutcher S . The effects of high-intensity intermittent exercise training on fat loss and fasting insulin levels of young women. Int J Obes (Lond). 2008; 32(4):684-91. DOI: 10.1038/sj.ijo.0803781. View

17.

Cho J, Ko J, Lim S . Relationship between metabolic syndrome and moderate-to-vigorous physical activity among adults 18 years old and over. PLoS One. 2021; 16(10):e0258097. PMC: 8513823. DOI: 10.1371/journal.pone.0258097. View

18.

Cabanas-Sanchez V, Guallar-Castillon P, Higueras-Fresnillo S, Rodriguez-Artalejo F, Martinez-Gomez D . Changes in Sitting Time and Cardiovascular Mortality in Older Adults. Am J Prev Med. 2018; 54(3):419-422. DOI: 10.1016/j.amepre.2017.10.010. View

19.

Byberg L, Zethelius B, McKeigue P, Lithell H . Changes in physical activity are associated with changes in metabolic cardiovascular risk factors. Diabetologia. 2002; 44(12):2134-9. DOI: 10.1007/s001250100022. View

20.

Bertrais S, Beyeme-Ondoua J, Czernichow S, Galan P, Hercberg S, Oppert J . Sedentary behaviors, physical activity, and metabolic syndrome in middle-aged French subjects. Obes Res. 2005; 13(5):936-44. DOI: 10.1038/oby.2005.108. View