Impact of Double-strand Breaks Induced by Uv Radiation on Neuroinflammation and Neurodegenerative Disorders

Overview

Journal Mol Biol Rep

Specialty Molecular Biology

Date 2024 Jun 8

PMID 38851636

Authors

Srilakshmi Vijayakumar

Beryl Vedha Yesudhason

Jenif Leo Anandharaj

Weslen Vedakumari Sathyaraj

Johnson Retnaraj Samuel Selvan Christyraj

Affiliations

Soon will be listed here.

Abstract

Exposure to UV affects the development and growth of a wide range of organisms. Nowadays, researchers are focusing on the impact of UV radiation and its underlying molecular mechanisms, as well as devising strategies to mitigate its harmful effects. Different forms of UV radiation, their typical exposure effects, the impact of UV on DNA integrity, and the deterioration of genetic material are discussed in this review; furthermore, we also review the effects of UV radiation that affect the biological functions of the organisms. Subsequently, we address the processes that aid organisms in navigating the damage in genetic material, neuroinflammation, and neurodegeneration brought on by UV-mediated double-strand breaks. To emphasize the molecular pathways, we conclude the review by going over the animal model studies that highlight the genes and proteins that are impacted by UV radiation.

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