Advances in the Study of Etiology and Molecular Mechanisms of Sensorineural Hearing Loss

Overview

Journal Cell Biochem Biophys

Specialties Biochemistry
Biophysics
Cell Biology

Date 2024 Jun 7

PMID 38849694

Authors

Cairong He

Hongcun Gai

Wen Zhao

Haiqin Zhang

Lin Lai

Chenyu Ding

Lin Chen

Jie Ding

Affiliations

Soon will be listed here.

Abstract

Sensorineural hearing loss (SNHL), a multifactorial progressive disorder, results from a complex interplay of genetic and environmental factors, with its underlying mechanisms remaining unclear. Several pathological factors are believed to contribute to SNHL, including genetic factors, ion homeostasis, cell apoptosis, immune inflammatory responses, oxidative stress, hormones, metabolic syndrome, human cytomegalovirus infection, mitochondrial damage, and impaired autophagy. These factors collectively interact and play significant roles in the onset and progression of SNHL. The present review offers a comprehensive overview of the various factors that contribute to SNHL, emphasizes recent developments in understanding its etiology, and explores relevant preventive and intervention measures.

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