Increasing Pre-exposure Prophylaxis (PrEP) in Primary Care: A Study Protocol for a Multi-level Intervention Using the Multiphase Optimization Strategy (MOST) Framework

Overview

Journal Contemp Clin Trials

Publisher Elsevier

Date 2024 Jun 7

PMID 38848935

Authors

Elizabeth Lockhart

DeAnne Turner

Kate Guastaferro

Laura A Szalacha

Herica Torres Alzate

Stephanie Marhefka

Bianca Pittiglio

Megan Dekker

Hsueh-Han Yeh

Logan Zelenak

Jeremy Toney

Sean Manogue

Brian K Ahmedani

Affiliations

Soon will be listed here.

Abstract

Background: In the United States, over 1.2 million people are living with HIV. This disease disproportionately affects men who have sex with men (MSM), people of color, youth and young adults, and transgender individuals. Pre-exposure prophylaxis (PrEP) is an effective HIV prevention method. Barriers exist for both primary care providers (PCPs) to prescribe PrEP and prevent patients from initiating PrEP.

Methods: This study, MOST: PrEP, follows the multiphase optimization strategy (MOST) framework. The purpose is to identify a multi-level intervention among patients and PCPs to increase PrEP prescriptions in primary care. First, feedback will be obtained from providers and patients via focus groups, then, suggestions related to the context-specific (provider and individual level) factors of intervention component delivery will be incorporated. Subsequently, a rigorous experiment will be conducted using a 2 factorial design focusing on priority populations for PrEP initiation. Provider components include computer-based simulation training and a best practice alert. Patient components include a tailored PrEP educational video and HIV risk assessment. Finally, the facilitators and barriers to implementing the intervention components will be qualitatively examined.

Conclusion: In this protocol paper, we describe the one of the first known multilevel MOST optimization trial in healthcare. Intervention components are to be delivered to patients and providers in a large healthcare system, based in an HIV Ending the Epidemic priority jurisdiction. If effective, this multi-level approach could be disseminated to providers and patients in other large healthcare systems to make a significant impact on HIV prevention.

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