Kidney Cancer and Potential Use of Urinary Extracellular Vesicles

Overview

Journal Oncol Rev

Specialty Oncology

Date 2024 Jun 7

PMID 38846051

Authors

Linh Nguy-Hoang Le

Javaria Munir

Eun-Bit Kim

Seongho Ryu

Affiliations

Soon will be listed here.

Abstract

Kidney cancer is the 14th most common cancer globally. The 5-year relative survival rate of kidney cancer at a localized stage is 92.9% and it declines to 17.4% in metastatic stage. Currently, the most accurate method of its diagnosis is tissue biopsy. However, the invasive and costly nature of biopsies makes it undesirable in many patients. Therefore, novel biomarkers for diagnosis and prognosis should be explored. Urinary extracellular vesicles (uEVs) are small vesicles (50-200 nm) in urine carrying nucleic acids, proteins and lipids as their cargos. These uEVs' cargos can provide non-invasive alternative to monitor kidney health. In this review, we have summarized recent studies investigating potential use of uEVs' cargos as biomarkers in kidney cancer for diagnosis, prognosis and therapeutic intervention.

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