Antibacterial Efficacy and Membrane Mechanism of Action of the -derived Non-ionic Lipopeptide, Serrawettin W2-FL10

Overview

Journal Microbiol Spectr

Specialty Microbiology

Date 2024 Jun 6

PMID 38842361

Authors

Tanya Decker

Marina Rautenbach

Sehaam Khan

Wesaal Khan

Affiliations

Soon will be listed here.

Abstract

Importance: Antimicrobial resistance is a major public health concern, urgently requiring antibacterial compounds exhibiting low adverse health effects. In this study, a novel antibacterial lipopeptide analog is described, serrawettin W2-FL10 (derived from ), with potent activity displayed against . Mechanistic studies revealed that W2-FL10 targets the cell membrane of , causing depolarization and permeabilization because of transmembrane lesions/pores, resulting in the leakage of intracellular components, possible cytosolic uptake of W2-FL10, and ultimately cell death. This study provides the first insight into the mode of action of a non-ionic lipopeptide. The low to moderate cytotoxicity of W2-FL10 also highlights its application as a promising therapeutic agent for the treatment of bacterial infections.

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