Factor VIII Promotes Angiogenesis and Vessel Stability Regulating Extracellular Matrix Proteins

Overview

Journal Haematologica

Specialty Hematology

Date 2024 Jun 6

PMID 38841804

Authors

Cristina Olgasi

Alessia Cucci

Ivan Molineris

Simone Assanelli

Francesca Anselmi

Chiara Borsotti

Chiara Sgromo

Andrea Lauria

Simone Merlin

Gillian E Walker

Salvatore Oliviero

Antonia Follenzi

Affiliations

Soon will be listed here.

Citing Articles

The Link Between Venous and Arterial Thrombosis: Is There a Role for Endothelial Dysfunction?.

Donadini M, Calcaterra F, Romualdi E, Ciceri R, Cancellara A, Lodigiani C Cells. 2025; 14(2).

PMID: 39851572 PMC: 11763525. DOI: 10.3390/cells14020144.

Bridging the Gap: Endothelial Dysfunction and the Role of iPSC-Derived Endothelial Cells in Disease Modeling.

Sgromo C, Cucci A, Venturin G, Follenzi A, Olgasi C Int J Mol Sci. 2025; 25(24.

PMID: 39769040 PMC: 11678083. DOI: 10.3390/ijms252413275.

Non-clinical investigations about cytotoxic and anti-platelet activities of gamma-terpinene.

Souza R, Pimentel V, de Sousa R, Sena E, da Silva A, Dittz D Naunyn Schmiedebergs Arch Pharmacol. 2024; 397(10):8145-8160.

PMID: 38801455 DOI: 10.1007/s00210-024-03173-w.

References

Chen Y, Mao C, Gu R, Zhao R, Li W, Ma Z . Nidogen-2 is a Novel Endogenous Ligand of LGR4 to Inhibit Vascular Calcification. Circ Res. 2022; 131(12):1037-1054. DOI: 10.1161/CIRCRESAHA.122.321614. View

Collins P, Blanchette V, Fischer K, Bjorkman S, Oh M, Fritsch S . Break-through bleeding in relation to predicted factor VIII levels in patients receiving prophylactic treatment for severe hemophilia A. J Thromb Haemost. 2009; 7(3):413-20. DOI: 10.1111/j.1538-7836.2008.03270.x. View

Biere-Rafi S, Tuinenburg A, Haak B, Peters M, Huijgen R, de Groot E . Factor VIII deficiency does not protect against atherosclerosis. J Thromb Haemost. 2011; 10(1):30-7. DOI: 10.1111/j.1538-7836.2011.04499.x. View

Olgasi C, Borsotti C, Merlin S, Bergmann T, Bittorf P, Adewoye A . Efficient and safe correction of hemophilia A by lentiviral vector-transduced BOECs in an implantable device. Mol Ther Methods Clin Dev. 2021; 23:551-566. PMC: 8606349. DOI: 10.1016/j.omtm.2021.10.015. View

Witjas F, van den Berg B, van den Berg C, Engelse M, Rabelink T . Concise Review: The Endothelial Cell Extracellular Matrix Regulates Tissue Homeostasis and Repair. Stem Cells Transl Med. 2018; 8(4):375-382. PMC: 6431685. DOI: 10.1002/sctm.18-0155. View

Randi A, Smith K, Castaman G . von Willebrand factor regulation of blood vessel formation. Blood. 2018; 132(2):132-140. PMC: 6182264. DOI: 10.1182/blood-2018-01-769018. View

Kjeld N, Hua B, Karsdal M, Sun S, Manon-Jensen T . The endothelial specific isoform of type XVIII collagen correlates to annual bleeding rate in haemophilia patients. PLoS One. 2018; 13(1):e0190375. PMC: 5761888. DOI: 10.1371/journal.pone.0190375. View

Cooke E, Zhou J, Wyseure T, Joshi S, Bhat V, Durden D . Vascular Permeability and Remodelling Coincide with Inflammatory and Reparative Processes after Joint Bleeding in Factor VIII-Deficient Mice. Thromb Haemost. 2018; 118(6):1036-1047. PMC: 6191040. DOI: 10.1055/s-0038-1641755. View

Sun H, Yang M, Fung M, Chan S, Jawi M, Anderson T . Adult males with haemophilia have a different macrovascular and microvascular endothelial function profile compared with healthy controls. Haemophilia. 2017; 23(5):777-783. DOI: 10.1111/hae.13278. View

10.

Follenzi A, Benten D, Novikoff P, Faulkner L, Raut S, Gupta S . Transplanted endothelial cells repopulate the liver endothelium and correct the phenotype of hemophilia A mice. J Clin Invest. 2008; 118(3):935-45. PMC: 2242617. DOI: 10.1172/JCI32748. View

11.

Gopal S, Barnes R, Cooke E, Zhou J, Levin I, Emery P . Systemic vascular basement membrane markers linked to synovial vascular remodeling are biomarkers of hemarthrosis in patients with hemophilia. J Thromb Haemost. 2021; 19(5):1200-1211. DOI: 10.1111/jth.15268. View

12.

Ishihara J, Ishihara A, Starke R, Peghaire C, Smith K, McKinnon T . The heparin binding domain of von Willebrand factor binds to growth factors and promotes angiogenesis in wound healing. Blood. 2019; 133(24):2559-2569. PMC: 6566593. DOI: 10.1182/blood.2019000510. View

13.

Davis G, Senger D . Endothelial extracellular matrix: biosynthesis, remodeling, and functions during vascular morphogenesis and neovessel stabilization. Circ Res. 2005; 97(11):1093-107. DOI: 10.1161/01.RES.0000191547.64391.e3. View

14.

Bolton-Maggs P, Pasi K . Haemophilias A and B. Lancet. 2003; 361(9371):1801-9. DOI: 10.1016/S0140-6736(03)13405-8. View

15.

Cooke E, Wyseure T, Zhou J, Gopal S, Nasamran C, Fisch K . Mechanisms of vascular permeability and remodeling associated with hemarthrosis in factor VIII-deficient mice. J Thromb Haemost. 2019; 17(11):1815-1826. PMC: 6824926. DOI: 10.1111/jth.14567. View

16.

Sartori M, Bilora F, Zanon E, Varvarikis C, Saggiorato G, Campagnolo E . Endothelial dysfunction in haemophilia patients. Haemophilia. 2008; 14(5):1055-62. DOI: 10.1111/j.1365-2516.2008.01808.x. View

17.

Mao C, Ma Z, Jia Y, Li W, Xie N, Zhao G . Nidogen-2 Maintains the Contractile Phenotype of Vascular Smooth Muscle Cells and Prevents Neointima Formation via Bridging Jagged1-Notch3 Signaling. Circulation. 2021; 144(15):1244-1261. DOI: 10.1161/CIRCULATIONAHA.120.053361. View