Right-sided Versus Left-sided Colorectal Cancer in Elderly Patients: a Sub-analysis of a Large Multicenter Case-control Study in Japan

Overview

Journal Surg Today

Specialty General Surgery

Date 2024 Jun 5

PMID 38839654

Authors

Haruki Sada

Takao Hinoi

Hiroaki Niitsu

Hideki Ohdan

Seiichiro Yamamoto

Shungo Endo

Koya Hida

Yusuke Kinugasa

Toshiyuki Enomoto

Satoshi Maruyama

Fumio Konishi

Masahiko Watanabe

Affiliations

Soon will be listed here.

Abstract

Purpose: This study investigated the impact of sidedness of colorectal cancer (CRC) in elderly patients on the prognosis.

Methods: In a sub-analysis of a multicenter case-control study of CRC patients who underwent surgery at ≥ 80 years old conducted in Japan between 2003 and 2007, both short- and long-term outcomes were compared between right-sided colon cancers (RCCs) and left-sided colorectal cancers (LCCs). RCCs were defined as those located from the cecum to the transverse colon.

Results: Among the 1680 patients who underwent curative surgery, 812 and 868 had RCCs and LCCs, respectively. RCCs were more frequent than LCCs in those who were female, had renal comorbidities, and had a history of abdominal surgery. Regarding tumor characteristics, RCCs were larger, invaded more deeply, and were diagnosed as either mucinous or signet ring-cell carcinoma more frequently than LCCs. Regarding the prognosis, patients with RCCs had a significantly longer cancer-specific survival (CS-S) and cancer-specific relapse-free survival (CS-RFS) than those with LCCs. Furthermore, sidedness was determined to be an independent prognostic factor for CS-S and CS-RFS.

Conclusion: RCCs, which accounted for half of the cases in patients ≥ 80 years old, showed better long-term outcomes than LCCs.

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