Dyslipidemia and ANGPTL8 Evaluation in Young Females with Type 1 Diabetes Mellitus

Overview

Journal Endocrine

Specialty Endocrinology

Date 2024 Jun 5

PMID 38836992

Authors

Walaa Mohammedsaeed

Dalal Binjawhar

Affiliations

Soon will be listed here.

Abstract

Purpose: ANGPTL8, commonly referred to as betatrophin, has demonstrated promise as a dependable marker for the onset of complications associated with diabetes mellitus, such as dyslipidemia. The objective of this study is to evaluate the lipid profile and ANGPTL8 levels in people diagnosed with Type 1 Diabetes Mellitus (T1DM).

Methods: A retrospective case-control study was performed on a group of 100 adolescent females, aged 13-17 years. This group consisted of individuals diagnosed with T1DM from the Diabetes and Endocrine Department at Medina's King Fahad Hospital in Saudi Arabia. Additionally, 100 healthy adolescent females of the same age range were included as controls. The hospital conducted laboratory studies to evaluate glucose, HbA1c, insulin, and lipid profiles. The ANGPTL8 levels were quantified using Enzyme-Linked Immunosorbent Assay (ELISA).

Results: Patients with T1DM had ANGPTL8 levels that were twice as high as those observed in individuals without any health conditions. The two groups had contrasting levels of fasting blood glucose (FBG), glycated hemoglobin (HbA1c), C-peptides, triacylglycerol (TG), and cholesterol, along with elevated Atherogenic Index of Plasma readings. Diabetes mellitus patients had considerably elevated values compared to the control group. There was a significant correlation between ANGPTL8 concentrations and lipid abnormalities, with P-values less than 0.05. 56% of the 100 patients exhibited dyslipidemia. The research found a correlation between dyslipidemia and elevated levels of ANGPTL8 in diabetic patients. The concentration of ANGPTL8 had a positive correlation with glucose, HbA1c, TG, and C-peptides while displaying a negative correlation with high-density lipoprotein cholesterol (HDL-C).

Conclusion: ANGPTL8 levels were found to be elevated in Saudi young women who were diagnosed with TIDM. ANGPTL8 may potentially contribute to dyslipidemia in individuals with T1DM, hence increasing the susceptibility to cardiovascular disease (CVD). Therefore, ANGPTL8 has the potential to impact lipid metabolism, namely Triglycerides, as a biological route. The results highlight the need to analyze lipid profiles and do ANGPTL8 testing in young females diagnosed with T1DM at an early stage to prevent complications.

References

Vetere A, Choudhary A, Burns S, Wagner B . Targeting the pancreatic β-cell to treat diabetes. Nat Rev Drug Discov. 2014; 13(4):278-89. DOI: 10.1038/nrd4231. View

Seymour P, Serup P . Bulking up on beta cells. N Engl J Med. 2013; 369(8):777-9. DOI: 10.1056/NEJMcibr1307038. View

Jiao Y, Le Lay J, Yu M, Naji A, Kaestner K . Elevated mouse hepatic betatrophin expression does not increase human β-cell replication in the transplant setting. Diabetes. 2013; 63(4):1283-8. PMC: 3964501. DOI: 10.2337/db13-1435. View

Maahs D, West N, Lawrence J, Mayer-Davis E . Epidemiology of type 1 diabetes. Endocrinol Metab Clin North Am. 2010; 39(3):481-97. PMC: 2925303. DOI: 10.1016/j.ecl.2010.05.011. View

Noorelahi M, Soubhanneyaz A, Kasim K . Perceptions, barriers, and practices of medical research among students at Taibah College of Medicine, Madinah, Saudi Arabia. Adv Med Educ Pract. 2015; 6:479-85. PMC: 4500619. DOI: 10.2147/AMEP.S83978. View

Abduljabbar M, Aljubeh J, Amalraj A, Cherian M . Incidence trends of childhood type 1 diabetes in eastern Saudi Arabia. Saudi Med J. 2010; 31(4):413-8. View

Verges B . Dyslipidemia in Type 1 Diabetes: AMaskedDanger. Trends Endocrinol Metab. 2020; 31(6):422-434. DOI: 10.1016/j.tem.2020.01.015. View

Fagundes Melo R, Fornari Laurindo L, Sloan K, Sloan L, Cressoni Araujo A, Bitelli P . Investigating the Incidence of Dyslipidemia among Brazilian Children and Adolescents Diagnosed with Type 1 Diabetes Mellitus: A Cross-Sectional Study. Diseases. 2024; 12(3). PMC: 10968983. DOI: 10.3390/diseases12030045. View

10.

Kim S, Jung I, Jeon Y, Cho W, Cho K, Park S . Serum lipid profiles and glycemic control in adolescents and young adults with type 1 diabetes mellitus. Ann Pediatr Endocrinol Metab. 2015; 19(4):191-6. PMC: 4316412. DOI: 10.6065/apem.2014.19.4.191. View

11.

Fu Z, Yao F, Abou-Samra A, Zhang R . Lipasin, thermoregulated in brown fat, is a novel but atypical member of the angiopoietin-like protein family. Biochem Biophys Res Commun. 2012; 430(3):1126-31. DOI: 10.1016/j.bbrc.2012.12.025. View

12.

Zhang R . Lipasin, a novel nutritionally-regulated liver-enriched factor that regulates serum triglyceride levels. Biochem Biophys Res Commun. 2012; 424(4):786-92. DOI: 10.1016/j.bbrc.2012.07.038. View

13.

Alrasheed A . Dyslipidemia Among Patients With Type 1 Diabetes and Its Associated Factors in Saudi Arabia: An Analytical Cross-Sectional Study. Cureus. 2022; 14(2):e21923. PMC: 8899866. DOI: 10.7759/cureus.21923. View

14.

Mangili L . High Prevalence of Dyslipidemia in Children and Adolescents: Opportunity for Prevention. Arq Bras Cardiol. 2020; 114(1):57-58. PMC: 7025315. DOI: 10.36660/abc.20190761. View

15.

Wang Y, Quagliarini F, Gusarova V, Gromada J, Valenzuela D, Cohen J . Mice lacking ANGPTL8 (Betatrophin) manifest disrupted triglyceride metabolism without impaired glucose homeostasis. Proc Natl Acad Sci U S A. 2013; 110(40):16109-14. PMC: 3791734. DOI: 10.1073/pnas.1315292110. View

16.

Yi P, Park J, Melton D . Retraction Notice to: Betatrophin: A Hormone that Controls Pancreatic β Cell Proliferation. Cell. 2017; 168(1-2):326. PMC: 5287220. DOI: 10.1016/j.cell.2016.12.017. View

17.

Chen P, Gao W, Liou J, Lin C, Wu M, Yen J . Angiopoietin-Like Protein 3 (ANGPTL3) Modulates Lipoprotein Metabolism and Dyslipidemia. Int J Mol Sci. 2021; 22(14). PMC: 8304944. DOI: 10.3390/ijms22147310. View

18.

Abu-Farha M, Sriraman D, Cherian P, AlKhairi I, Elkum N, Behbehani K . Circulating ANGPTL8/Betatrophin Is Increased in Obesity and Reduced after Exercise Training. PLoS One. 2016; 11(1):e0147367. PMC: 4718617. DOI: 10.1371/journal.pone.0147367. View

19.

Fenzl A, Itariu B, Kosi L, Fritzer-Szekeres M, Kautzky-Willer A, Stulnig T . Circulating betatrophin correlates with atherogenic lipid profiles but not with glucose and insulin levels in insulin-resistant individuals. Diabetologia. 2014; 57(6):1204-8. DOI: 10.1007/s00125-014-3208-x. View

20.

Dewey F, Gusarova V, Dunbar R, ODushlaine C, Schurmann C, Gottesman O . Genetic and Pharmacologic Inactivation of ANGPTL3 and Cardiovascular Disease. N Engl J Med. 2017; 377(3):211-221. PMC: 5800308. DOI: 10.1056/NEJMoa1612790. View

21.

Stitziel N, Khera A, Wang X, Bierhals A, Vourakis A, Sperry A . ANGPTL3 Deficiency and Protection Against Coronary Artery Disease. J Am Coll Cardiol. 2017; 69(16):2054-2063. PMC: 5404817. DOI: 10.1016/j.jacc.2017.02.030. View