YTHDF1's Grip on CRC Vasculature: Insights into LINC01106 and MiR-449b-5p-VEGFA Axis

Overview

Journal Cancer Cell Int

Publisher Biomed Central

Date 2024 Jun 4

PMID 38835070

Authors

Rui-Ting Ma

Yuanyuan Wang

Feng Ji

Jian-Nan Chen

Tian-Jun Wang

Yan Liu

Ming-Xing Hou

Zhi-Gang Guo

Affiliations

Soon will be listed here.

Abstract

Background: Investigating the unexplored territory of lncRNA m6A modification in colorectal cancer (CRC) vasculature, this study focuses on LINC01106 and YTHDF1.

Methods: Clinical assessments reveal upregulated LINC01106 promoting vascular generation via the miR-449b-5p-VEGFA pathway.

Results: YTHDF1, elevated in CRC tissues, emerges as an adverse prognostic factor. Functional experiments showcase YTHDF1's inhibitory effects on CRC cell dynamics. Mechanistically, Me-CLIP identifies m6A-modified LINC01106, validated as a YTHDF1 target through Me-RIP.

Conclusions: This study sheds light on the YTHDF1-mediated m6A modification of LINC01106, presenting it as a key player in suppressing CRC vascular generation.

References

Zou G, Zhang X, Wang L, Li X, Xie T, Zhao J . Herb-sourced emodin inhibits angiogenesis of breast cancer by targeting VEGFA transcription. Theranostics. 2020; 10(15):6839-6853. PMC: 7295066. DOI: 10.7150/thno.43622. View

Wang L, Zhu L, Liang C, Huang X, Liu Z, Huo J . Targeting N6-methyladenosine reader YTHDF1 with siRNA boosts antitumor immunity in NASH-HCC by inhibiting EZH2-IL-6 axis. J Hepatol. 2023; 79(5):1185-1200. DOI: 10.1016/j.jhep.2023.06.021. View

Wang S, Gao S, Zeng Y, Zhu L, Mo Y, Wong C . N6-Methyladenosine Reader YTHDF1 Promotes ARHGEF2 Translation and RhoA Signaling in Colorectal Cancer. Gastroenterology. 2021; 162(4):1183-1196. DOI: 10.1053/j.gastro.2021.12.269. View

Bao Y, Zhai J, Chen H, Wong C, Liang C, Ding Y . Targeting mA reader YTHDF1 augments antitumour immunity and boosts anti-PD-1 efficacy in colorectal cancer. Gut. 2023; 72(8):1497-1509. PMC: 10359538. DOI: 10.1136/gutjnl-2022-328845. View

Sung H, Ferlay J, Siegel R, Laversanne M, Soerjomataram I, Jemal A . Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2021; 71(3):209-249. DOI: 10.3322/caac.21660. View

An Y, Duan H . The role of m6A RNA methylation in cancer metabolism. Mol Cancer. 2022; 21(1):14. PMC: 8753874. DOI: 10.1186/s12943-022-01500-4. View

Gu Y, Huang Y, Sun Y, Liang X, Kong L, Liu Z . [Long non-coding RNA LINC01106 regulates colorectal cancer cell proliferation and apoptosis through the STAT3 pathway]. Nan Fang Yi Ke Da Xue Xue Bao. 2020; 40(9):1259-1264. PMC: 7544581. DOI: 10.12122/j.issn.1673-4254.2020.09.06. View

Li J, Zhang H, Wang H . N-methyladenosine modification in cancer biology: Current status and future perspectives. Comput Struct Biotechnol J. 2022; 20:6578-6585. PMC: 9712505. DOI: 10.1016/j.csbj.2022.11.045. View

Behera J, Kumar A, Voor M, Tyagi N . Exosomal lncRNA-H19 promotes osteogenesis and angiogenesis through mediating Angpt1/Tie2-NO signaling in CBS-heterozygous mice. Theranostics. 2021; 11(16):7715-7734. PMC: 8315071. DOI: 10.7150/thno.58410. View

10.

Shen H, Yu H, Li Q, Wei Y, Fu J, Dong H . Hepatocyte-derived VEGFA accelerates the progression of non-alcoholic fatty liver disease to hepatocellular carcinoma via activating hepatic stellate cells. Acta Pharmacol Sin. 2022; 43(11):2917-2928. PMC: 9622738. DOI: 10.1038/s41401-022-00907-5. View

11.

Wang C, Zhou M, Zhu P, Ju C, Sheng J, Du D . IGF2BP2-induced circRUNX1 facilitates the growth and metastasis of esophageal squamous cell carcinoma through miR-449b-5p/FOXP3 axis. J Exp Clin Cancer Res. 2022; 41(1):347. PMC: 9753396. DOI: 10.1186/s13046-022-02550-8. View

12.

Shen M, Li Y, Wang Y, Shao J, Zhang F, Yin G . N-methyladenosine modification regulates ferroptosis through autophagy signaling pathway in hepatic stellate cells. Redox Biol. 2021; 47:102151. PMC: 8495178. DOI: 10.1016/j.redox.2021.102151. View

13.

Rebello D, Rebello E, Custodio M, Xu X, Gandhi S, Roy H . Field carcinogenesis for risk stratification of colorectal cancer. Adv Cancer Res. 2021; 151:305-344. DOI: 10.1016/bs.acr.2021.03.004. View

14.

Gao X, Yu L, Zhang J, Xue P . Silencing of Long Non-Coding RNA LINC01106 Suppresses the Proliferation, Migration and Invasion of Endometrial Cancer Cells Through Regulating the miR-449a/MET Axis. Onco Targets Ther. 2020; 13:9643-9655. PMC: 7532893. DOI: 10.2147/OTT.S264642. View

15.

Mao R, Wang Z, Zhang Y, Chen Y, Liu Q, Zhang T . Development and validation of a novel prognostic signature in gastric adenocarcinoma. Aging (Albany NY). 2020; 12(21):22233-22252. PMC: 11623975. DOI: 10.18632/aging.104161. View

16.

Liu J, Tian C, Qiao J, Deng K, Ye X, Xiong L . m6A Methylation-Mediated Stabilization of LINC01106 Suppresses Bladder Cancer Progression by Regulating the miR-3148/DAB1 Axis. Biomedicines. 2024; 12(1). PMC: 10813768. DOI: 10.3390/biomedicines12010114. View

17.

Zheng L, Tang X, Lu M, Sun S, Xie S, Cai J . microRNA-421-3p prevents inflammatory response in cerebral ischemia/reperfusion injury through targeting m6A Reader YTHDF1 to inhibit p65 mRNA translation. Int Immunopharmacol. 2020; 88:106937. DOI: 10.1016/j.intimp.2020.106937. View

18.

Cheng L, Shi X, Huo D, Zhao Y, Zhang H . MiR-449b-5p regulates cell proliferation, migration and radioresistance in cervical cancer by interacting with the transcription suppressor FOXP1. Eur J Pharmacol. 2019; 856:172399. DOI: 10.1016/j.ejphar.2019.05.028. View

19.

Jiang X, Liu B, Nie Z, Duan L, Xiong Q, Jin Z . The role of m6A modification in the biological functions and diseases. Signal Transduct Target Ther. 2021; 6(1):74. PMC: 7897327. DOI: 10.1038/s41392-020-00450-x. View

20.

Zhao L, Zhou Y, Zhao Y, Li Q, Zhou J, Mao Y . Long non-coding RNA TUSC8 inhibits breast cancer growth and metastasis via miR-190b-5p/MYLIP axis. Aging (Albany NY). 2020; 12(3):2974-2991. PMC: 7041739. DOI: 10.18632/aging.102791. View