Disease Progression in Proposed Brain-first and Body-first Parkinson's Disease Subtypes

Overview

Journal NPJ Parkinsons Dis

Date 2024 Jun 4

PMID 38834646

Authors

Zhiheng Xu

Tianyu Hu

Chenqin Xu

Xiaoniu Liang

Shiyu Li

Yimin Sun

Fengtao Liu

Jian Wang

Yilin Tang

Affiliations

Soon will be listed here.

Abstract

A new Parkinson's disease (PD) subtyping model has been recently proposed based on the initial location of α-synuclein inclusions, which divides PD patients into the brain-first subtype and the body-first subtype. Premotor RBD has proven to be a predictive marker of the body-first subtype. We found compared to PD patients without possible RBD (PD, representing the brain-first subtype), PD patients with possible premotor RBD (PD, representing the body-first subtype) had lower Movement Disorders Society Unified Parkinson's Disease Rating Scale part III (MDS UPDRS-III) score (p = 0.022) at baseline but presented a faster progression rate (p = 0.009) in MDS UPDRS-III score longitudinally. The above finding indicates the body-first subtype exhibited a faster disease progression in motor impairments compared to the brain-first subtype and further validates the proposed subtyping model.

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