The Efficacy and Tolerability of Proteoglycan F in the Treatment of Knee Osteoarthritis: A Prospective, Randomized, Double-blind Controlled Trial

Overview

Journal Osteoarthr Cartil Open

Date 2024 Jun 4

PMID 38832051

Authors

Huyen Thi Thanh Vu

Huong Thi Thu Nguyen

Thu Thi Hoai Nguyen

Thanh Xuan Nguyen

Tam Ngoc Nguyen

Anh Lan Nguyen

Luong Thi Hong Nguyen

Huyen Thi La

Hien Thi Thu Vu

Quyen Thi Tu Bui

Thu Nguyet Nghiem

Arunasiri Iddamalgoda

Kenichi Ito

Tatsuji Takahashi

Tuyen Danh Le

Thang Pham

Anh Trung Nguyen

Affiliations

Soon will be listed here.

Abstract

Objective: To identify the efficacy and tolerability of Proteoglycan F in patients with primary knee OA.: A 24-week randomized, placebo-controlled, double-blind clinical trial with two arms: (1) Proteoglycan F (received 10 mg proteoglycan daily, for 24 weeks) and (2) control group (received placebo). Knee symptoms and joint cartilage status (evaluated by ultrasound and MRI of knee joints), quality of life, serum cytokine levels IL-1β and TNF-α), and safety evaluation were measured before, during, and after the treatment.

Results: After 24-week treatment, pain reduction (in the KOOS pain score) of at least 20% and at least 50% (NRS scale) compared to baseline in the PGF group was significantly higher than those in the control group. The PGF group had greater reductions in the total scores of subchondral bone marrow edema, and bone cocoon under cartilage on knee MRI (classification according to WORMs), which were -2.27 (-4.0; -0.51) and -1.77 (-3.08; -0.46), respectively (p < 0.05). The two groups had no statistically significant difference in knee ultrasound characteristics. After 4 weeks, 12, and 24 weeks compared to baseline, there was no statistically significant difference in levels of urea, creatinine, aspartate aminotransferase, and alanine aminotransferase within the group and between the two study groups.

Conclusions: Salmon cartilage PG with 10 mg per day has potential to improve pain symptoms and subchondral bone marrow edema and bone cocoon under cartilage lesions in primary knee OA. However, the efficacy of PGF should be viewed with caution, and future studies are needed for more specific evaluation.

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