Stem Cell Therapy As a Promising Approach for Ischemic Stroke Treatment

Overview

Journal Curr Res Pharmacol Drug Discov

Date 2024 Jun 4

PMID 38831867

Authors

Sahar Yaqubi

Mohammad Karimian

Affiliations

Soon will be listed here.

Abstract

Ischemia as the most common type of stroke is the main cause of death and disability in the world. However, there are few therapeutic approaches to treat ischemic stroke. The common approach to the treatment of ischemia includes surgery-cum-chemical drugs. Surgery and chemical drugs are used to remove blood clots to prevent the deterioration of the nervous system. Given the surgical hazards and the challenges associated with chemical drugs, these cannot be considered safe approaches to the treatment of brain ischemia. Besides surgery-cum-chemical drugs, different types of stem cells including mesenchymal stem cells and neurological stem cells have been considered to treat ischemic stroke. Therapeutic approaches utilizing stem cells to treat strokes are promising because of their neuroprotective and regenerative benefits. However, the mechanisms by which the transplanted stem cells perform their precisely actions are unknown. The purpose of this study is to critically review stem cell-based therapeutic approaches for ischemia along with related challenges.

References

Lasala G, Silva J, Kusnick B, Minguell J . Combination stem cell therapy for the treatment of medically refractory coronary ischemia: a Phase I study. Cardiovasc Revasc Med. 2011; 12(1):29-34. DOI: 10.1016/j.carrev.2010.01.001. View

Liu X, Ye R, Yan T, Yu S, Wei L, Xu G . Cell based therapies for ischemic stroke: from basic science to bedside. Prog Neurobiol. 2013; 115:92-115. PMC: 4038267. DOI: 10.1016/j.pneurobio.2013.11.007. View

Paitazoglou C, Bergmann M, Vrtovec B, Chamuleau S, van Klarenbosch B, Wojakowski W . Rationale and design of the European multicentre study on Stem Cell therapy in IschEmic Non-treatable Cardiac diseasE (SCIENCE). Eur J Heart Fail. 2019; 21(8):1032-1041. PMC: 6774320. DOI: 10.1002/ejhf.1412. View

Jiang Y, Zhu W, Zhu J, Wu L, Xu G, Liu X . Feasibility of delivering mesenchymal stem cells via catheter to the proximal end of the lesion artery in patients with stroke in the territory of the middle cerebral artery. Cell Transplant. 2012; 22(12):2291-8. DOI: 10.3727/096368912X658818. View

Wang F, Tang H, Zhu J, Zhang J . Transplanting Mesenchymal Stem Cells for Treatment of Ischemic Stroke. Cell Transplant. 2018; 27(12):1825-1834. PMC: 6300770. DOI: 10.1177/0963689718795424. View

Amariglio N, Hirshberg A, Scheithauer B, Cohen Y, Loewenthal R, Trakhtenbrot L . Donor-derived brain tumor following neural stem cell transplantation in an ataxia telangiectasia patient. PLoS Med. 2009; 6(2):e1000029. PMC: 2642879. DOI: 10.1371/journal.pmed.1000029. View

Hinkle J, Guanci M . Acute ischemic stroke review. J Neurosci Nurs. 2007; 39(5):285-93, 310. DOI: 10.1097/01376517-200710000-00005. View

Yamashita T, Ninomiya M, Hernandez Acosta P, Garcia-Verdugo J, Sunabori T, Sakaguchi M . Subventricular zone-derived neuroblasts migrate and differentiate into mature neurons in the post-stroke adult striatum. J Neurosci. 2006; 26(24):6627-36. PMC: 6674034. DOI: 10.1523/JNEUROSCI.0149-06.2006. View

Moshayedi P, Nih L, Llorente I, Berg A, Cinkornpumin J, Lowry W . Systematic optimization of an engineered hydrogel allows for selective control of human neural stem cell survival and differentiation after transplantation in the stroke brain. Biomaterials. 2016; 105:145-155. PMC: 5003628. DOI: 10.1016/j.biomaterials.2016.07.028. View

10.

Liu Z, Li Y, Zhang Z, Cui X, Cui Y, Lu M . Bone marrow stromal cells enhance inter- and intracortical axonal connections after ischemic stroke in adult rats. J Cereb Blood Flow Metab. 2010; 30(7):1288-95. PMC: 2896436. DOI: 10.1038/jcbfm.2010.8. View

11.

Tremonti C, Thieben M . Drugs in secondary stroke prevention. Aust Prescr. 2021; 44(3):85-90. PMC: 8236871. DOI: 10.18773/austprescr.2021.018. View

12.

Bang O, Kim E, Cho Y, Oh M, Chung J, Chang W . Circulating Extracellular Vesicles in Stroke Patients Treated With Mesenchymal Stem Cells: A Biomarker Analysis of a Randomized Trial. Stroke. 2022; 53(7):2276-2286. DOI: 10.1161/STROKEAHA.121.036545. View

13.

Oyamada N, Itoh H, Sone M, Yamahara K, Miyashita K, Park K . Transplantation of vascular cells derived from human embryonic stem cells contributes to vascular regeneration after stroke in mice. J Transl Med. 2008; 6:54. PMC: 2567291. DOI: 10.1186/1479-5876-6-54. View

14.

Caplan A, Correa D . The MSC: an injury drugstore. Cell Stem Cell. 2011; 9(1):11-5. PMC: 3144500. DOI: 10.1016/j.stem.2011.06.008. View

15.

Khassafi N, Zahraei Z, Vahidinia Z, Karimian M, Azami Tameh A . Calcitriol Pretreatment Attenuates Glutamate Neurotoxicity by Regulating NMDAR and CYP46A1 Gene Expression in Rats Subjected to Transient Middle Cerebral Artery Occlusion. J Neuropathol Exp Neurol. 2022; 81(4):252-259. DOI: 10.1093/jnen/nlac011. View

16.

Takahashi K, Yamanaka S . Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell. 2006; 126(4):663-76. DOI: 10.1016/j.cell.2006.07.024. View

17.

Bang O, Lee J, Lee P, Lee G . Autologous mesenchymal stem cell transplantation in stroke patients. Ann Neurol. 2005; 57(6):874-82. DOI: 10.1002/ana.20501. View

18.

Eckert M, Vu Q, Xie K, Yu J, Liao W, Cramer S . Evidence for high translational potential of mesenchymal stromal cell therapy to improve recovery from ischemic stroke. J Cereb Blood Flow Metab. 2013; 33(9):1322-34. PMC: 3764389. DOI: 10.1038/jcbfm.2013.91. View

19.

Patel S, Meyer J, Greco S, Corcoran K, Bryan M, Rameshwar P . Mesenchymal stem cells protect breast cancer cells through regulatory T cells: role of mesenchymal stem cell-derived TGF-beta. J Immunol. 2010; 184(10):5885-94. DOI: 10.4049/jimmunol.0903143. View

20.

Hochain P, Capet C, Colin R . [Digestive complications of aspirin]. Rev Med Interne. 2000; 21 Suppl 1:50s-59s. DOI: 10.1016/s0248-8663(00)88725-1. View