Are MiR-26a and MiR-26b MicroRNAs Potent Prognostic Markers of Gestational Diabetes?

Overview

Journal Health Sci Rep

Specialty General Medicine

Date 2024 Jun 4

PMID 38831779

Authors

Hori Ghaneialvar

Mahdieh Mehrab Mohseni

Azra Kenarkoohi

Saeed Kakaee

Affiliations

Soon will be listed here.

Abstract

Background: Gestational diabetes mellitus is a common public health problem, accompanied by complications for the mother and fetus. So, introducing new biomarkers to identify early diabetes is essential. As serum miRNAs are potentially appropriate markers, we investigated miR-26a and miR-26b expression levels in pregnant women with and without gestational diabetes.

Method: Demographic and clinical characteristics of 40 gestational diabetic patients and 40 healthy controls were assessed. The expression level of miR-26a and miR-26b microRNAs was measured by real-time PCR. Statistical analysis was done with GraphPad Prism software (version 8.4.3).

Result: The findings of this study showed that the expression level of miR-26a and miR-26b increased in women with gestational diabetes compared with healthy pregnant women, but the increase in expression was only significant for miR-26a ( < 0.05).

Conclusion: According to the statistical and ROC curves, we suggest miR-26a as a potential biomarker for the early diagnosis of gestational diabetes mellitus.

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