Compact and Cost-effective Laser-powered Speckle Contrast Optical Spectroscopy Fiber-free Device for Measuring Cerebral Blood Flow

Overview

Journal J Biomed Opt

Specialties Biomedical Engineering
Ophthalmology

Date 2024 Jun 3

PMID 38826808

Authors

Yu Xi Huang

Simon Mahler

Maya Dickson

Aidin Abedi

Julian Michael Tyszka

Yu Tung Lo

Jonathan Russin

Charles Liu

Changhuei Yang

Affiliations

Soon will be listed here.

Abstract

Significance: In the realm of cerebrovascular monitoring, primary metrics typically include blood pressure, which influences cerebral blood flow (CBF) and is contingent upon vessel radius. Measuring CBF noninvasively poses a persistent challenge, primarily attributed to the difficulty of accessing and obtaining signal from the brain.

Aim: Our study aims to introduce a compact speckle contrast optical spectroscopy device for noninvasive CBF measurements at long source-to-detector distances, offering cost-effectiveness, and scalability while tracking blood flow (BF) with remarkable sensitivity and temporal resolution.

Approach: The wearable sensor module consists solely of a laser diode and a board camera. It can be easily placed on a subject's head to measure BF at a sampling rate of 80 Hz.

Results: Compared to the single-fiber-based version, the proposed device achieved a signal gain of about 70 times, showed superior stability, reproducibility, and signal-to-noise ratio for measuring BF at long source-to-detector distances. The device can be distributed in multiple configurations around the head.

Conclusions: Given its cost-effectiveness, scalability, and simplicity, this laser-centric tool offers significant potential in advancing noninvasive cerebral monitoring technologies.

Citing Articles

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